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从分数阶角度分析具有不完善疫苗接种效果的媒介传播感染的动力学。

Analysis of the dynamics of a vector-borne infection with the effect of imperfect vaccination from a fractional perspective.

机构信息

Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan.

School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan.

出版信息

Sci Rep. 2023 Sep 1;13(1):14398. doi: 10.1038/s41598-023-41440-7.

Abstract

The burden of vector-borne infections is significant, particularly in low- and middle-income countries where vector populations are high and healthcare infrastructure may be inadequate. Further, studies are required to investigate the key factors of vector-borne infections to provide effective control measure. This study focuses on formulating a mathematical framework to characterize the spread of chikungunya infection in the presence of vaccines and treatments. The research is primarily dedicated to descriptive study and comprehension of dynamic behaviour of chikungunya dynamics. We use Banach's and Schaefer's fixed point theorems to investigate the existence and uniqueness of the suggested chikungunya framework resolution. Additionally, we confirm the Ulam-Hyers stability of the chikungunya system. To assess the impact of various parameters on the dynamics of chikungunya, we examine solution pathways using the Laplace-Adomian method of disintegration. Specifically, to visualise the impacts of fractional order, vaccination, bite rate and treatment computer algorithms are employed on the infection level of chikungunya. Our research identified the framework's essential input settings for managing chikungunya infection. Notably, the intensity of chikungunya infection can be reduced by lowering mosquito bite rates in the affected area. On the other hand, vaccination, memory index or fractional order, and treatment could be used as efficient controlling variables.

摘要

虫媒传染病的负担很大,特别是在中低收入国家,这些国家的病媒种群数量较高,医疗保健基础设施可能不足。此外,还需要研究虫媒传染病的关键因素,以提供有效的控制措施。本研究的重点是制定一个数学框架,以描述在存在疫苗和治疗的情况下基孔肯雅热感染的传播。该研究主要致力于描述性研究和对基孔肯雅热动力学的动态行为的理解。我们使用巴拿赫和斯凯夫的不动点定理来研究所提出的基孔肯雅热框架解的存在性和唯一性。此外,我们还证实了基孔肯雅热系统的乌尔曼-海耶斯稳定性。为了评估各种参数对基孔肯雅热动力学的影响,我们使用拉普拉斯-阿达姆方法对解路径进行了分析。具体来说,为了可视化分数阶、疫苗接种、叮咬率和治疗对基孔肯雅热感染水平的影响,我们在感染水平上对计算机算法进行了分析。我们的研究确定了管理基孔肯雅热感染的框架的基本输入设置。值得注意的是,可以通过降低疫区蚊子的叮咬率来降低基孔肯雅热感染的强度。另一方面,可以将疫苗接种、记忆指数或分数阶和治疗作为有效的控制变量。

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