Cao Shujun, Zhang Kun, Li Qiujing, Zhang Shukun, Chen Jingdi
Marine College, Shandong University, Weihai 264209, China.
Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai 264299, China.
Carbohydr Polym. 2023 Nov 15;320:121239. doi: 10.1016/j.carbpol.2023.121239. Epub 2023 Jul 27.
For irregular and deep skin wounds, it's difficult for wound dressing to reach the injured site to achieve rapid hemostasis and provide wound protection. Bacterial cellulose (BC) has high strength and natural three-dimensional pore structure, which endows it shape recovery ability after absorbing blood when injected to the wound. Therefore, in the study, an injectable aldehyde bacterial cellulose/polydopamine (DBC/PDA) photothermal cryogel was prepared by oxidation polymerization method for hemostasis and repair of irregular and deep skin wounds. BC was oxidized by NaIO to form DBC and dopamine (DA) was introduced into DBC by reacting with the aldehyde group in DBC through Schiff base reaction. Under oxidation effect of NaIO and with freezing condition, water crystallization led to local aggregation of DA and DBC, and at the same time DA was oxidized to PDA and polymerized with DA on DBC. After the melting process, the porous cryogel was obtained. The introduction of PDA enhances the photothermal properties of DBC/PDA cryogel. DBC/PDA cryogel can kill most bacteria and provide wound protection under near-infrared light. In vitro and in vivo hemostatic tests show that the DBC/PDA cryogel can quickly absorb blood and stop bleeding. Combined with its good injectable, DBC/PDA cryogel can provide rapid hemostatic and protection in the face of irregular and deep skin wounds.
对于不规则且较深的皮肤伤口，伤口敷料难以到达受伤部位以实现快速止血并提供伤口保护。细菌纤维素（BC）具有高强度和天然的三维孔隙结构，这使其在注入伤口吸收血液后具有形状恢复能力。因此，在本研究中，通过氧化聚合法制备了一种可注射的醛基细菌纤维素/聚多巴胺（DBC/PDA）光热冷冻凝胶，用于不规则且较深皮肤伤口的止血和修复。BC通过NaIO氧化形成DBC，多巴胺（DA）通过席夫碱反应与DBC中的醛基反应引入到DBC中。在NaIO的氧化作用和冷冻条件下，水结晶导致DA和DBC局部聚集，同时DA被氧化为PDA并与DBC上的DA聚合。经过融化过程后，得到多孔冷冻凝胶。PDA的引入增强了DBC/PDA冷冻凝胶的光热性能。DBC/PDA冷冻凝胶在近红外光下可杀死大多数细菌并提供伤口保护。体外和体内止血试验表明，DBC/PDA冷冻凝胶能快速吸收血液并止血。结合其良好的可注射性，DBC/PDA冷冻凝胶在面对不规则且较深的皮肤伤口时可提供快速止血和保护。
