Chang Jinlong, Sun Xuming
School of Medical Engineering, Xinxiang Medical University, Xinxiang, China.
Xinxiang Key Laboratory of Neurobiosensor, Xinxiang Medical University, Xinxiang, China.
Front Bioeng Biotechnol. 2023 Aug 21;11:1255782. doi: 10.3389/fbioe.2023.1255782. eCollection 2023.
Bioprinting is an emerging field that utilizes 3D printing technology to fabricate intricate biological structures, including tissues and organs. Among the various promising bioprinting techniques, laser-induced forward transfer (LIFT) stands out by employing a laser to precisely transfer cells or bioinks onto a substrate, enabling the creation of complex 3D architectures with characteristics of high printing precision, enhanced cell viability, and excellent technical adaptability. This technology has found extensive applications in the production of biomolecular microarrays and biological structures, demonstrating significant potential in tissue engineering. This review briefly introduces the experimental setup, bioink ejection mechanisms, and parameters relevant to LIFT bioprinting. Furthermore, it presents a detailed summary of both conventional and cutting-edge applications of LIFT in fabricating biomolecule microarrays and various tissues, such as skin, blood vessels and bone. Additionally, the review addresses the existing challenges in this field and provides corresponding suggestions. By contributing to the ongoing development of this field, this review aims to inspire further research on the utilization of LIFT-based bioprinting in biomedical applications.
生物打印是一个新兴领域，它利用3D打印技术制造复杂的生物结构，包括组织和器官。在各种有前景的生物打印技术中，激光诱导正向转移（LIFT）脱颖而出，它通过使用激光将细胞或生物墨水精确转移到基板上，能够创建具有高打印精度、增强的细胞活力和出色技术适应性的复杂3D结构。该技术已在生物分子微阵列和生物结构的生产中得到广泛应用，在组织工程中显示出巨大潜力。本文简要介绍了LIFT生物打印的实验装置、生物墨水喷射机制和相关参数。此外，它详细总结了LIFT在制造生物分子微阵列和各种组织（如皮肤、血管和骨骼）方面的传统和前沿应用。此外，本文还讨论了该领域现有的挑战并提供了相应的建议。通过为该领域的持续发展做出贡献，本文旨在激发对基于LIFT的生物打印在生物医学应用中的进一步研究。
