Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, c/ Profesor García González 2, Seville 41012, Spain.
Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Escuela Politécnica Superior, c/ Virgen de África 7, Seville 41011, Spain.
ACS Appl Mater Interfaces. 2022 Apr 6;14(13):15008-15020. doi: 10.1021/acsami.2c01241. Epub 2022 Mar 22.
In this research work, the fabrication of biphasic composite implants has been investigated. Porous, commercially available pure Ti (50 vol % porosity and pore distributions of 100-200, 250-355, and 355-500 μm) has been used as a cortical bone replacement, while different composites based on a polymer blend (gelatin and alginate) and bioactive glass (BG) 45S5 have been applied as a soft layer for cartilage tissues. The microstructure, degradation rates, biofunctionality, and wear behavior of the different composites were analyzed to find the best possible coating. Experiments demonstrated the best micromechanical balance for the substrate containing 200-355 μm size range distribution. In addition, although the coating prepared from alginate presented a lower mass loss, the composite containing 50% alginate and 50% gelatin showed a higher elastic recovery, which entails that this type of coating could replicate the functions of the soft tissue in areas of the joints. Therefore, results revealed that the combinations of porous commercially pure Ti and composites prepared from alginate/gelatin/45S5 BG are candidates for the fabrication of biphasic implants not only for the treatment of osteochondral defects but also potentially for any other diseases affecting simultaneously hard and soft tissues.
本研究工作探讨了双相复合植入物的制备。多孔商用纯钛（孔隙率为 50%，孔径分布为 100-200μm、250-355μm 和 355-500μm）用作皮质骨替代物，而基于聚合物共混物（明胶和藻酸盐）和生物活性玻璃（BG）45S5 的不同复合材料用作软骨组织的软层。分析了不同复合材料的微观结构、降解率、生物功能性和磨损行为，以找到最佳的涂层。实验表明，含有 200-355μm 尺寸分布范围的基底具有最佳的微小机械平衡。此外，尽管藻酸盐制备的涂层质量损失较低，但含有 50%藻酸盐和 50%明胶的复合材料具有更高的弹性回复率，这意味着这种类型的涂层可以复制关节区域软组织的功能。因此，结果表明，多孔商用纯钛与藻酸盐/明胶/45S5BG 复合材料的组合是制备双相植入物的候选材料，不仅可用于治疗骨软骨缺损，还可能用于治疗同时影响硬组织和软组织的任何其他疾病。
