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A historical perspective of biomedical explainable AI research.

作者信息

Malinverno Luca, Barros Vesna, Ghisoni Francesco, Visonà Giovanni, Kern Roman, Nickel Philip J, Ventura Barbara Elvira, Šimić Ilija, Stryeck Sarah, Manni Francesca, Ferri Cesar, Jean-Quartier Claire, Genga Laura, Schweikert Gabriele, Lovrić Mario, Rosen-Zvi Michal

机构信息

Porini SRL, Via Cavour, 222074 Lomazzo, Italy.

AI for Accelerated Healthcare & Life Sciences Discovery, IBM R&D Laboratories, University of Haifa Campus, Mount Carmel, Haifa 3498825, Israel.

出版信息

Patterns (N Y). 2023 Sep 8;4(9):100830. doi: 10.1016/j.patter.2023.100830.


DOI:10.1016/j.patter.2023.100830
PMID:37720333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10500028/
Abstract

The black-box nature of most artificial intelligence (AI) models encourages the development of explainability methods to engender trust into the AI decision-making process. Such methods can be broadly categorized into two main types: post hoc explanations and inherently interpretable algorithms. We aimed at analyzing the possible associations between COVID-19 and the push of explainable AI (XAI) to the forefront of biomedical research. We automatically extracted from the PubMed database biomedical XAI studies related to concepts of causality or explainability and manually labeled 1,603 papers with respect to XAI categories. To compare the trends pre- and post-COVID-19, we fit a change point detection model and evaluated significant changes in publication rates. We show that the advent of COVID-19 in the beginning of 2020 could be the driving factor behind an increased focus concerning XAI, playing a crucial role in accelerating an already evolving trend. Finally, we present a discussion with future societal use and impact of XAI technologies and potential future directions for those who pursue fostering clinical trust with interpretable machine learning models.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/10500028/e7c1fa908893/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/10500028/2852886d46b4/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/10500028/ad454c354246/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/10500028/2ed0d1b68bb1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/10500028/e7c1fa908893/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/10500028/2852886d46b4/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/10500028/ad454c354246/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/10500028/2ed0d1b68bb1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a345/10500028/e7c1fa908893/gr3.jpg

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A historical perspective of biomedical explainable AI research.

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本文引用的文献

[1]
Performance of ChatGPT on USMLE: Potential for AI-assisted medical education using large language models.

PLOS Digit Health. 2023-2-9

[2]
Application of explainable artificial intelligence for healthcare: A systematic review of the last decade (2011-2022).

Comput Methods Programs Biomed. 2022-11

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A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies.

J Biomed Sci. 2022-9-12

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AI-SCoRE (artificial intelligence-SARS CoV2 risk evaluation): a fast, objective and fully automated platform to predict the outcome in COVID-19 patients.

Radiol Med. 2022-9

[5]
Causal machine learning for healthcare and precision medicine.

R Soc Open Sci. 2022-8-3

[6]
ProtGPT2 is a deep unsupervised language model for protein design.

Nat Commun. 2022-7-27

[7]
Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead.

Nat Mach Intell. 2019-5

[8]
PNEUMONIA DETECTION ON CHEST X-RAY USING RADIOMIC FEATURES AND CONTRASTIVE LEARNING.

Proc IEEE Int Symp Biomed Imaging. 2021-4

[9]
AI in small-molecule drug discovery: a coming wave?

Nat Rev Drug Discov. 2022-3

[10]
AI in health and medicine.

Nat Med. 2022-1

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