Civitan International Research Center, University of Alabama at Birmingham, 1719 6th Ave S Suite:252B, Birmingham, AL, 35233, USA.
Department of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Sci Rep. 2023 Sep 24;13(1):15956. doi: 10.1038/s41598-023-43132-8.
Alterations in P300 amplitude and latency, as well as neuropsychological tests, are informative to detect early signs of the affected high cognitive processing in Mild Cognitive Impairment (MCI). In the present study, we examined P300 latency and amplitude elicited by visual oddball paradigm in 20 participants with MCI and age, education, and sex-matched healthy controls from frontal, central, and parietal midline electrodes. We performed a mixed-design ANOVA to compare P300 amplitude and latency between groups during target and non-target stimulus presentation. We also assessed the correlation between our electrophysiology findings and neuropsychological tests. Our results indicated that in healthy individuals P300 is elicited earlier in target stimulus processing compared to non-target stimulus processing. On the contrary, in the MCI group, P300 latency was increased during target processing compared to non-target stimulus processing. Moreover, P300 latency in target processing is prolonged in the MCI group compared to controls. Also, our correlation results showed a significant correlation between P300 peak latency and amplitude, and attention required cognitive tasks. In conclusion, our results provide evidence that high-order cognitive processes that are involved in stimulus processing slows down in individuals with MCI due to the high working memory demand for neural processing.
P300 波幅和潜伏期的改变，以及神经心理学测试，对于检测轻度认知障碍（MCI）中受影响的高认知处理的早期迹象是有帮助的。在本研究中，我们从额、中、顶中线电极检查了 20 名 MCI 参与者和年龄、教育和性别匹配的健康对照组在视觉Oddball 范式下的 P300 潜伏期和振幅。我们进行了混合设计方差分析，以比较在目标和非目标刺激呈现期间组间的 P300 振幅和潜伏期。我们还评估了我们的电生理学发现与神经心理学测试之间的相关性。我们的结果表明，在健康个体中，与非目标刺激处理相比，目标刺激处理中 P300 更早激发。相反，在 MCI 组中，与非目标刺激处理相比，目标处理中的 P300 潜伏期增加。此外，与对照组相比，MCI 组中目标处理中的 P300 潜伏期延长。此外，我们的相关性结果表明，P300 峰潜伏期和振幅与注意力要求的认知任务之间存在显著相关性。总之，我们的结果提供了证据，表明由于神经处理对工作记忆的高需求，涉及刺激处理的高阶认知过程在 MCI 个体中会减慢。
