Zheng Jianuo, Wang Yunping, Wang Yuwen, Duan Ruiping, Liu Lingrong
Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
Gels. 2023 Sep 13;9(9):742. doi: 10.3390/gels9090742.
The application of hydrogels in bone repair is limited due to their low mechanical strength. Simulating bone extracellular matrix, methylacrylylated gelatin (GelMA)/methylacrylylated hyaluronic acid (HAMA)/nano-hydroxyapatite(nHap) composite hydrogels were prepared by combining the double network strategy and composite of nHap in this study. The precursor solutions of the composite hydrogels were injectable due to their shear thinning property. The compressive elastic modulus of the composite hydrogel was significantly enhanced, the fracture strength of the composite hydrogel nearly reached 1 MPa, and the composite hydrogel retained its high water content at above 88%. The composite hydrogels possess good compatibility with BMSC and have the potential to be used as injectable hydrogels for bone defect treatment.
由于水凝胶的机械强度较低，其在骨修复中的应用受到限制。在本研究中，通过结合双网络策略和纳米羟基磷灰石（nHap）的复合，制备了模拟骨细胞外基质的甲基丙烯酰化明胶（GelMA）/甲基丙烯酰化透明质酸（HAMA）/纳米羟基磷灰石（nHap）复合水凝胶。复合水凝胶的前驱体溶液因其剪切变稀特性而具有可注射性。复合水凝胶的压缩弹性模量显著提高，复合水凝胶的断裂强度接近1 MPa，并且复合水凝胶在88%以上仍保持其高含水量。该复合水凝胶与骨髓间充质干细胞（BMSC）具有良好的相容性，有潜力用作治疗骨缺损的可注射水凝胶。
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