Spyrakis Francesca, Dragani Tommaso A
Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Aspidia srl, 20100 Milan, Italy.
Toxics. 2023 Aug 22;11(9):721. doi: 10.3390/toxics11090721.
The proposal by the European Chemicals Agency (ECHA) to ban over 12,000 per- and polyfluoroalkyl substances (PFAS) has sparked a debate about potential consequences for the economy, industry, and the environment. Although some PFAS are known to be harmful, a blanket ban may lead to significant problems in attempting to replace PFAS-based materials for environmental transition, as well as in medical devices and everyday products. Alternative materials may potentially be less safe, as a rush to replace PFAS would reduce the time needed for toxicological analyses. Studies have shown that PFAS exhibit a diverse range of mechanisms of action, biopersistence, and bioaccumulation potential, and should thus not be treated as a single group. This is particularly true for the class of fluoropolymers. A targeted approach that considers the specific risks and benefits of each chemical may be more effective. Moreover, the proposed ban may also have unintended consequences for the environment as PFAS use is also associated with benefits such as reducing greenhouse-gas emissions and improving energy efficiency. Policymakers must carefully weigh up the potential consequences before making a final decision on the ban.
欧洲化学品管理局(ECHA)提出禁止12000多种全氟和多氟烷基物质(PFAS)的提议,引发了一场关于对经济、工业和环境潜在影响的辩论。尽管已知某些PFAS有害,但全面禁令可能会在尝试替代基于PFAS的材料以实现环境转型以及在医疗设备和日常产品方面引发重大问题。替代材料可能安全性较低,因为急于替代PFAS会减少毒理学分析所需的时间。研究表明,PFAS表现出多种作用机制、生物持久性和生物累积潜力,因此不应将其视为单一类别。对于含氟聚合物类别尤其如此。考虑每种化学品的特定风险和益处的针对性方法可能更有效。此外,拟议的禁令可能还会对环境产生意想不到的后果,因为PFAS的使用也与减少温室气体排放和提高能源效率等益处相关。政策制定者在就禁令做出最终决定之前,必须仔细权衡潜在后果。