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噬菌体生物工程:一种用于靶向药物发现及其他领域的变革性方法。

Bacteriophage Bioengineering: A Transformative Approach for Targeted Drug Discovery and Beyond.

作者信息

Cui Longzhu, Veeranarayanan Srivani, Thitiananpakorn Kanate, Wannigama Dhammika Leshan

机构信息

Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.

Department of Infectious Diseases and Infection Control, Yamagata Prefectural Central Hospital, Yamagata 990-2292, Japan.

出版信息

Pathogens. 2023 Sep 20;12(9):1179. doi: 10.3390/pathogens12091179.

DOI:10.3390/pathogens12091179
PMID:37764987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10534869/
Abstract

Bacteriophages, the viruses that infect and replicate within bacteria, have long been recognized as potential therapeutic agents against bacterial infections [...].

摘要

噬菌体是在细菌内感染并复制的病毒,长期以来一直被认为是对抗细菌感染的潜在治疗剂[……]。

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Bacteriophage Bioengineering: A Transformative Approach for Targeted Drug Discovery and Beyond.噬菌体生物工程:一种用于靶向药物发现及其他领域的变革性方法。
Pathogens. 2023 Sep 20;12(9):1179. doi: 10.3390/pathogens12091179.
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Bacteriophages as Therapeutic Agents: Alternatives to Antibiotics.作为治疗剂的噬菌体:抗生素的替代品
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Bacteriophages against enteropathogens: rediscovery and refinement of novel antimicrobial therapeutics.抗肠病原体噬菌体:新型抗菌治疗药物的重新发现和改进。
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Exploring bacteriophage therapy for drug-resistant bacterial infections.探索噬菌体疗法治疗耐药菌感染。
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Bacteriophage therapy as an alternative treatment for human infections. A comprehensive review.噬菌体疗法作为人类感染的一种替代治疗方法。全面综述。
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Bacteriophage therapy: an overview and the position of Italian Society of Infectious and Tropical Diseases.噬菌体疗法:概述及意大利传染病与热带病学会的立场
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[Bacteriophages as antibacterial agents].[噬菌体作为抗菌剂]
Harefuah. 2004 Feb;143(2):121-5, 166.
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Bacteriophage Therapeutics: A Primer for Clinicians on Phage-Antibiotic Combinations.噬菌体治疗学:临床医生实用噬菌体-抗生素联合治疗基础
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Bacteriophage therapy for management of bacterial infections in veterinary practice: what was once old is new again.兽医实践中用于治疗细菌感染的噬菌体疗法:曾经的旧方法如今再度兴起。
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[Bacteriophage therapy].[噬菌体疗法]
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引用本文的文献

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Synthetic and Functional Engineering of Bacteriophages: Approaches for Tailored Bactericidal, Diagnostic, and Delivery Platforms.噬菌体的合成与功能工程:定制杀菌、诊断和递送平台的方法
Molecules. 2025 Jul 25;30(15):3132. doi: 10.3390/molecules30153132.
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Comparative analysis of immune responses to intraperitoneal administration of lytic E. coli bacteriophages in mice.小鼠腹腔注射溶菌性大肠杆菌噬菌体后免疫反应的比较分析
Virus Res. 2025 Jul 19;359:199610. doi: 10.1016/j.virusres.2025.199610.
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Addressing the global challenge of bacterial drug resistance: insights, strategies, and future directions.应对细菌耐药性的全球挑战:见解、策略与未来方向。
Front Microbiol. 2025 Feb 24;16:1517772. doi: 10.3389/fmicb.2025.1517772. eCollection 2025.
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Phage therapy could be key to conquering persistent bacterial lung infections in children.噬菌体疗法可能是攻克儿童持续性肺部细菌感染的关键。
NPJ Antimicrob Resist. 2024 Oct 10;2(1):31. doi: 10.1038/s44259-024-00045-4.
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Phage therapeutic delivery methods and clinical trials for combating clinically relevant pathogens.用于对抗临床相关病原体的噬菌体治疗递送方法及临床试验。
Ther Deliv. 2025 Mar;16(3):247-269. doi: 10.1080/20415990.2024.2426824. Epub 2024 Nov 15.
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A Comprehensive Review on Phage Therapy and Phage-Based Drug Development.噬菌体疗法与基于噬菌体的药物开发综述
Antibiotics (Basel). 2024 Sep 11;13(9):870. doi: 10.3390/antibiotics13090870.
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Characterization of a  phage vB_AbaM-SHI and its inhibition effect on biofilms of .噬菌体制备及其对. 生物膜抑制效果的表征。
Front Cell Infect Microbiol. 2024 Mar 8;14:1351993. doi: 10.3389/fcimb.2024.1351993. eCollection 2024.

本文引用的文献

1
Enhancing bacteriophage therapeutics through in situ production and release of heterologous antimicrobial effectors.通过原位生产和释放异源抗菌效应物来增强噬菌体疗法。
Nat Commun. 2023 Jul 20;14(1):4337. doi: 10.1038/s41467-023-39612-0.
2
Phage-Inducible Chromosomal Islands as a Diagnostic Platform to Capture and Detect Bacterial Pathogens.噬菌体诱导的染色体岛作为一种诊断平台,用于捕获和检测细菌病原体。
Adv Sci (Weinh). 2023 Aug;10(24):e2301643. doi: 10.1002/advs.202301643. Epub 2023 Jun 26.
3
Engineering bacteriophages for enhanced host range and efficacy: insights from bacteriophage-bacteria interactions.工程改造噬菌体以扩大宿主范围并提高疗效:噬菌体与细菌相互作用的见解
Front Microbiol. 2023 May 31;14:1172635. doi: 10.3389/fmicb.2023.1172635. eCollection 2023.
4
Developing Phage Therapy That Overcomes the Evolution of Bacterial Resistance.开发克服细菌耐药性进化的噬菌体疗法。
Annu Rev Virol. 2023 Sep 29;10(1):503-524. doi: 10.1146/annurev-virology-012423-110530. Epub 2023 Jun 2.
5
Engineered Phage-Based Cancer Vaccines: Current Advances and Future Directions.工程化噬菌体癌症疫苗:当前进展与未来方向
Vaccines (Basel). 2023 Apr 29;11(5):919. doi: 10.3390/vaccines11050919.
6
Translating phage therapy into the clinic: Recent accomplishments but continuing challenges.将噬菌体疗法转化为临床应用:近期的成就与持续的挑战。
PLoS Biol. 2023 May 23;21(5):e3002119. doi: 10.1371/journal.pbio.3002119. eCollection 2023 May.
7
Current Clinical Landscape and Global Potential of Bacteriophage Therapy.噬菌体疗法的当前临床现状和全球潜力。
Viruses. 2023 Apr 21;15(4):1020. doi: 10.3390/v15041020.
8
Modified Bacteriophage for Tumor Detection and Targeted Therapy.用于肿瘤检测和靶向治疗的改良噬菌体
Nanomaterials (Basel). 2023 Feb 8;13(4):665. doi: 10.3390/nano13040665.
9
Bacteriophage-Based Biosensors: A Platform for Detection of Foodborne Bacterial Pathogens from Food and Environment.基于噬菌体的生物传感器:从食物和环境中检测食源性病原体细菌的平台。
Biosensors (Basel). 2022 Oct 21;12(10):905. doi: 10.3390/bios12100905.
10
CRISPR-Cas9 Based Bacteriophage Genome Editing.基于 CRISPR-Cas9 的噬菌体基因组编辑。
Microbiol Spectr. 2022 Aug 31;10(4):e0082022. doi: 10.1128/spectrum.00820-22. Epub 2022 Jul 26.