AD 奥德赛 2023：单细胞的故事。

The AD odyssey 2023: Tales of single cell.

机构信息

Helen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.

出版信息

Cell. 2023 Sep 28;186(20):4257-4259. doi: 10.1016/j.cell.2023.09.001.

DOI:10.1016/j.cell.2023.09.001

PMID:37774675

Abstract

Deciphering cellular changes in Alzheimer's disease (AD) using large cohorts with defined clinical stages is essential for understanding the diverse trajectories of AD progression. In this issue of Cell, five studies harnessed the power of single-nuclei RNA sequencing (snRNA-seq) and single-nuclei ATAC sequencing (snATAC-seq) at unprecedented scale and revealed exciting insights into cell-type-specific mechanisms underlying the progression of AD pathogenesis.

摘要

利用具有明确临床阶段的大型队列来破译阿尔茨海默病 (AD) 中的细胞变化，对于理解 AD 进展的不同轨迹至关重要。在本期《Cell》杂志上，五项研究利用前所未有的规模进行了单细胞 RNA 测序 (snRNA-seq) 和单细胞 ATAC 测序 (snATAC-seq)，揭示了 AD 发病机制进展中细胞类型特异性机制的令人兴奋的见解。