Lei Chak Seng, Lin Xuanqiao, Ning Rui, Yu Jinjin, Huang Xiaomin, Li Kexin, Wang Yiran, Savini Giacomo, Schiano-Lomoriello Domenico, Zhou Xingtao, Huang Jinhai
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, No. 19 Baoqing Road, Xuhui District, Shanghai, 200031, China.
NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.
Ophthalmol Ther. 2023 Dec;12(6):3263-3279. doi: 10.1007/s40123-023-00815-9. Epub 2023 Oct 3.
The aim of this work is to evaluate the intraobserver repeatability and interobserver reproducibility of corneal power measurements obtained with a swept-source optical coherence tomographer (CASIA 2, Tomey, Japan) in healthy subjects.
A total of 67 right eyes from 67 healthy subjects were enrolled. Two experienced observers measured each eye three times consecutively with the CASIA 2. Corneal power values were recorded as simulated keratometry, anterior, posterior, and total corneal power. Parameters were flattest keratometry (K), steepest keratometry (K), mean keratometry (K), astigmatism magnitude, astigmatism power vectors J and J. Intraobserver repeatability and interobserver reproducibility of the CASIA 2 were assessed by the within-subject standard deviation (S), test-retest repeatability (TRT), coefficients of variation (CoV), and intraclass correlation coefficients (ICCs). Double-angle plots were used for astigmatism vector analysis.
The CASIA 2 had high repeatability for all corneal power values, with S values ≤ 0.17 diopters (D), TRT ≤ 0.46 D, and ICCs ranging from 0.866 to 0.998. Interobserver reproducibility was also high, showing all S values ≤ 0.10 D, TRT ≤ 0.27 D, and ICCs ≥ 0.944. The reproducibility of the average of three consecutive measurements (S 0.01-0.10 D, TRT 0.03-0.27 D, ICC 0.944-0.998) was higher than the reproducibility of single measurements (S 0.01-0.17 D, TRT 0.03-0.47 D, ICC 0.867-0.996).
The CASIA 2 showed high intraobserver repeatability and interobserver reproducibility for anterior, posterior, and total corneal power measurements in 6.0-mm diameter area. In addition, we suggest that using the average of three consecutive measurements can improve reproducibility between observers, compared to single measurements only.
本研究旨在评估使用扫频光学相干断层扫描仪（CASIA 2，日本多美公司）对健康受试者进行角膜屈光力测量时，观察者内重复性和观察者间再现性。
共纳入67名健康受试者的67只右眼。两名经验丰富的观察者使用CASIA 2对每只眼睛连续测量三次。角膜屈光力值记录为模拟角膜曲率、前表面、后表面和总角膜屈光力。参数包括最平角膜曲率（K）、最陡角膜曲率（K）、平均角膜曲率（K）、散光量、散光屈光力矢量J和J。通过受试者内标准差（S）、重测重复性（TRT）、变异系数（CoV）和组内相关系数（ICC）评估CASIA 2的观察者内重复性和观察者间再现性。使用双角图进行散光矢量分析。
CASIA 2对所有角膜屈光力值均具有高重复性，S值≤0.17屈光度（D），TRT≤0.46 D，ICC范围为0.866至0.998。观察者间再现性也很高，所有S值≤0.10 D，TRT≤0.27 D，ICC≥0.944。连续三次测量平均值的再现性（S 0.01 - 0.10 D，TRT 0.03 - 0.27 D，ICC 0.944 - 0.998）高于单次测量的再现性（S 0.01 - 0.17 D，TRT 0.03 - 0.47 D，ICC 0.867 - 0.996）。
CASIA 2在6.0毫米直径区域内对前表面、后表面和总角膜屈光力测量显示出高观察者内重复性和观察者间再现性。此外，我们建议与仅进行单次测量相比，使用连续三次测量的平均值可提高观察者间的再现性。
