Anthoulaki Xanthi, Oikonomou Efthimios, Bothou Anastasia, Papanikolopoulou Stavroula, Nikolettos Konstantinos, Damaskos Christos, Garbis Nikolaos, Kyriakou Dimitrios, Nalbanti Theopi, Iatrakis Georgios, Nikolettos Nikolaos, Tsikouras Panagiotis
Department of Obstetrics and Gynecology, Democritus University of Thrace, Greece.
Nikolaos Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, Athens, Greece and Renal Transplantation Unit, Laiko General Hospital, Athens, Greece.
Mater Sociomed. 2023 Sep;35(3):234-243. doi: 10.5455/msm.2023.35.234-243.
Pregnancy is an admirable biological process, resulting in significant changes in many of the body's normal systems so that they can support the development of the fetus. These changes involve hormonal changes, weight gain, immune system regulation, and others that need to be synchronized to maintain both maternal and fetal health.
The purpose of this study was to compare gut microbiome in neonates born by caesarean section and vaginal seeding with gut microbiomes of neonates born by caesarean section without vaginal seeding and neonates born by vaginal delivery.
In Democritus University of Thrace, from 2019 to 2022, gut microbiomes were compared for three groups of neonates. Group A included 110 neonates born by CS who underwent vaginal seeding, group B included 85 neonates born by CS without vaginal seeding and group C included 95 neonates born by vaginal delivery.
Vaginal seeding in neonates born with CS resulted in gut microbiome which was similar to the gut microbiome of neonates born by vaginal delivery (including lactobacillus species and bacteroides). On the contrary, gut microbiome of neonates born by CS without vaginal seeding was "limited".
According to our findings, vaginal seeding alters the gut microbiome of the neonates born with CS. However, there is a need for further investigation to prove its efficacy and its safety for the neonate.
怀孕是一个令人钦佩的生理过程，会导致身体许多正常系统发生显著变化，以便它们能够支持胎儿的发育。这些变化包括激素变化、体重增加、免疫系统调节等，需要相互协调以维持母婴健康。
本研究的目的是比较剖宫产并进行阴道播种的新生儿的肠道微生物群与未进行阴道播种的剖宫产新生儿及阴道分娩新生儿的肠道微生物群。
在色雷斯德谟克利特大学，从2019年到2022年，对三组新生儿的肠道微生物群进行了比较。A组包括110例剖宫产并接受阴道播种的新生儿，B组包括85例未进行阴道播种的剖宫产新生儿，C组包括95例阴道分娩的新生儿。
剖宫产出生的新生儿进行阴道播种后，其肠道微生物群与阴道分娩新生儿的肠道微生物群相似（包括乳酸杆菌属和拟杆菌属）。相反，未进行阴道播种的剖宫产新生儿的肠道微生物群“有限”。
根据我们的研究结果，阴道播种改变了剖宫产出生的新生儿的肠道微生物群。然而，需要进一步研究以证明其对新生儿的有效性和安全性。
