Abdallah Nehad A, Ahmed Sameh A, Almaghrabi Mohammed, Alahmadi Yaser M
Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Mounawarah 30001, Saudi Arabia.
Clinical and Hospital Pharmacy Department, College of Pharmacy, Taibah University, Al-Madinah Al-Mounawarah 30001, Saudi Arabia.
Polymers (Basel). 2023 Oct 4;15(19):3991. doi: 10.3390/polym15193991.
Current fundamental electrochemical research shows the potential of utilizing polymeric nanostructured materials as ion-to-electron transducers. In this paper, aniline was polymerized in the presence of TiO and CuO nanoparticles to yield a bimetallic/PANI nanocomposite. It was applied as a transducer in a carbon paste electrode for the potentiometric determination of vildagliptin in the presence of 18-crown-6-ether as a recognition element. The electrode's potentiometric performance was studied according to the IUPAC guidelines. It exhibited a wide linearity range of 1 × 10 M to 1 × 10 M, remarkable sensitivity (LOD of 4.5 × 10 M), and a fast response time of 10 s ± 1.3. The sensor did not show any potential drift due to the absence of the water layer between the carbon paste and the metallic conductor. This endowed the sensor with high stability and a long lifetime, as 137 days passed without the need to change the carbon paste surface. The electrode was utilized for the determination of the concentration of vildagliptin in bulk, pharmaceutical tablets, and human plasma, with average recovery ranging from 97.65% to 100.03%.
当前的基础电化学研究表明，利用聚合物纳米结构材料作为离子到电子的换能器具有潜力。在本文中，苯胺在二氧化钛和氧化铜纳米颗粒存在下聚合，以制备双金属/聚苯胺纳米复合材料。它被用作碳糊电极中的换能器，在18-冠-6-醚作为识别元件的情况下，用于电位法测定维格列汀。根据国际纯粹与应用化学联合会（IUPAC）的指导方针研究了该电极的电位性能。它表现出1×10⁻⁶ M至1×10⁻² M的宽线性范围、显著的灵敏度（检测限为4.5×10⁻⁷ M）以及10 s±1.3的快速响应时间。由于碳糊和金属导体之间不存在水层，该传感器没有显示出任何电位漂移。这赋予了传感器高稳定性和长寿命，因为经过137天无需更换碳糊表面。该电极用于测定散装、药片中以及人血浆中维格列汀的浓度，平均回收率在97.65%至100.03%之间。
