翻译后的蛋白质合成不需要热休克蛋白来诱导翻译机制的热稳定性。
No heat shock protein synthesis is required for induced thermostabilization of translational machinery.
作者信息
Hallberg R L
出版信息
Mol Cell Biol. 1986 Jun;6(6):2267-70. doi: 10.1128/mcb.6.6.2267-2270.1986.
Abstract
For Tetrahymena thermophila cells to survive at 43 degrees C, a normally lethal temperature, they require a pretreatment which either elicits the synthesis of heat shock proteins or one which brings about a change in the translational machinery of the cell such that is is not inactivated when transferred to 43 degrees C. In this report I present evidence showing that the latter modification can occur in the complete absence of protein synthesis, indicating that heat shock protein production is not required for the induced thermostabilization of the translational machinery.
摘要
嗜热四膜虫细胞要在43摄氏度（一个通常致命的温度）下存活，它们需要进行预处理，这种预处理要么引发热休克蛋白的合成，要么导致细胞翻译机制发生变化，使其在转移到43摄氏度时不会失活。在本报告中，我提供的证据表明，后一种修饰可以在完全没有蛋白质合成的情况下发生，这表明热休克蛋白的产生对于翻译机制的诱导热稳定性不是必需的。
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