Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, USA.
Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Nucleic Acids Res. 2024 Jan 5;52(D1):D850-D858. doi: 10.1093/nar/gkad887.
Studies of model organisms have provided important insights into how natural genetic differences shape trait variation. These discoveries are driven by the growing availability of genomes and the expansive experimental toolkits afforded to researchers using these species. For example, Caenorhabditis elegans is increasingly being used to identify and measure the effects of natural genetic variants on traits using quantitative genetics. Since 2016, the C. elegans Natural Diversity Resource (CeNDR) has facilitated many of these studies by providing an archive of wild strains, genome-wide sequence and variant data for each strain, and a genome-wide association (GWA) mapping portal for the C. elegans community. Here, we present an updated platform, the Caenorhabditis Natural Diversity Resource (CaeNDR), that enables quantitative genetics and genomics studies across the three Caenorhabditis species: C. elegans, C. briggsae and C. tropicalis. The CaeNDR platform hosts several databases that are continually updated by the addition of new strains, whole-genome sequence data and annotated variants. Additionally, CaeNDR provides new interactive tools to explore natural variation and enable GWA mappings. All CaeNDR data and tools are accessible through a freely available web portal located at caendr.org.
对模式生物的研究为了解自然遗传差异如何塑造性状变异提供了重要的见解。这些发现得益于基因组的日益普及，以及使用这些物种的研究人员可获得的广泛实验工具包。例如，秀丽隐杆线虫越来越多地被用于使用定量遗传学来识别和衡量自然遗传变异对性状的影响。自 2016 年以来，秀丽隐杆线虫自然多样性资源（CeNDR）通过提供野生品系档案、每个品系的全基因组序列和变异数据以及秀丽隐杆线虫社区的全基因组关联（GWA）映射门户，促进了许多此类研究。在这里，我们介绍了一个经过更新的平台，即秀丽隐杆线虫自然多样性资源（CaeNDR），它支持跨越秀丽隐杆线虫、C. briggsae 和 C. tropicalis 三个物种的定量遗传学和基因组学研究。CaeNDR 平台托管了几个数据库，这些数据库通过添加新的品系、全基因组序列数据和注释变体不断更新。此外，CaeNDR 提供了新的交互式工具来探索自然变异并支持 GWA 映射。所有 CaeNDR 数据和工具均可通过位于 caendr.org 的免费网络门户访问。
