Dongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Department of Pharmacy, The First People's Hospital of FoShan (Affiliated FoShan Hospital of Sun Yat-sen University), Foshan 528000, China.
Curr Med Chem. 2021;28(30):6179-6198. doi: 10.2174/0929867328666210511014129.
To date, number of new and attractive materials have been applied in drug delivery systems (DDDs) to improve the efficiency of the treatment of cancers. Some problems like low stability, toxicity and weak ability of targeting have hampered most of materials for further applications in biomedicine. MIL(MIL = Materials of Institute Lavoisier), as a specific subclass of metal-organic frameworks (MOFs) owns more advantages than other subclass MOFs, such as better biodegradability and lower cytotoxicity. However, until now, systematic -s and analyses of Fe-based MIL on medical applications are rarely though the majority of documents discussed one research branch of the porous materials MOFs.
In this review, we have focussed mainly on the latest studies of applications, including bioimaging, biosensing, and antibacterial and drug delivery on Fe-based MIL. The existing shortcomings and future perspectives of the rapidly growing biomedical applications of Fe-based MIL materials addressing dosage and loading strategies issues are also discussed briefly, and further studies with the use of different therapies will be of great interest.
This article reviews the Fe-based MOFs design and biomedical application, including biosensing, bioimaging, antibacterial agent, and drug delivery in recent years.
迄今为止，许多新型且有吸引力的材料已被应用于药物传递系统（DDDs）中，以提高癌症治疗的效率。但大多数材料仍存在稳定性低、毒性和靶向能力弱等问题，限制了其在生物医学领域的进一步应用。MIL（MIL = Institute Lavoisier 材料）作为金属有机骨架（MOFs）的一个特定亚类，比其他亚类 MOFs 具有更多优势，例如更好的生物降解性和更低的细胞毒性。然而，到目前为止，虽然大多数文献都讨论了多孔材料 MOFs 的一个研究分支，但对于铁基 MIL 在医学应用上的系统研究和分析却很少。
在这篇综述中，我们主要关注了铁基 MIL 在生物成像、生物传感、抗菌和药物传递等应用方面的最新研究进展。还简要讨论了铁基 MIL 材料在快速发展的生物医学应用中存在的剂量和载药策略问题及未来展望，使用不同疗法的进一步研究将具有很大的意义。
本文综述了近年来铁基 MOFs 在生物传感、生物成像、抗菌剂和药物传递等生物医学领域的设计和应用。
