Coggon D, Pannett B, Winter P D, Acheson E D, Bonsall J
Scand J Work Environ Health. 1986 Oct;12(5):448-54. doi: 10.5271/sjweh.2113.
The authors examined the mortality and cancer incidence of employees at a company which has manufactured, formulated, and sprayed 2 methyl-4 chlorophenoxyacetic acid (MCPA) and other phenoxy acid herbicides. Ninety-eight percent of the 5,784 men employed by the company during 1947-1975 was traced to the end of 1983. The overall mortality of the cohort was less than that of the national population, as was mortality from cancer. When allowance was made for rural residence, the deficit of cancer deaths became a slight excess, but not statistically significantly so. Among workers whose jobs entailed potential exposure to MCPA, there was one death from soft tissue sarcoma (0.6 expected). No further cases of soft tissue sarcoma were registered among living members of the cohort. Three potentially exposed workers died from nasal carcinoma, but this tumor has not previously been associated with phenoxy herbicides and the cluster of cases may have occurred by chance. The findings do not exclude the possibility that MCPA is a human carcinogen, but they suggest that any risk of soft tissue sarcoma is less than that indicated by earlier studies of 2,4,5-T (2,4,5-trichlorophenoxyacetic acid) and 2,4,5-trichlorophenol and is small in absolute terms.
作者研究了一家生产、配制和喷洒2-甲基-4-氯苯氧乙酸（MCPA）及其他苯氧羧酸类除草剂的公司员工的死亡率和癌症发病率。在1947年至1975年期间受雇于该公司的5784名男性中，98%被追踪至1983年底。该队列的总体死亡率低于全国人口，癌症死亡率也是如此。考虑到农村居住因素后，癌症死亡人数的不足变为略有超出，但在统计学上无显著差异。在工作中可能接触MCPA的工人中，有1人死于软组织肉瘤（预期为0.6例）。在该队列的在世成员中未再登记到软组织肉瘤病例。3名可能接触过的工人死于鼻咽癌，但此前该肿瘤与苯氧羧酸类除草剂并无关联，这组病例可能是偶然发生的。这些发现并不排除MCPA是人类致癌物的可能性，但表明软组织肉瘤的任何风险均低于早期对2,4,5-T（2,4,5-三氯苯氧乙酸）和2,4,5-三氯苯酚研究显示的风险，且从绝对数值来看风险较小。
