Freeman W R, Thomas E L, Rao N A, Pepose J S, Trousdale M D, Howes E L, Nadel A J, Mines J A, Bowe B
Am J Ophthalmol. 1986 Dec 15;102(6):701-9. doi: 10.1016/0002-9394(86)90396-x.
Tissue for pathologic examination was obtained from three cases of acute retinal necrosis syndrome. Virus particles belonging to the herpesvirus family were demonstrated in retinal biopsies from two patients, one of whom was immunosuppressed. Despite removal of large biopsy specimens, the retina has remained attached for 20 months postoperatively in one case and for three months in the other. In a third patient with acquired immune deficiency syndrome, the clinical course and postmortem immunopathology were suggestive of a herpes simplex virus infection, initially affecting the retina and subsequently the optic nerves, chiasm, tracts, and central nervous system. These cases illustrate that the virus associated with the acute retinal necrosis syndrome is easily demonstrable using vitrectomy and endoretinal biopsy in the acute phase of the disease, but may be difficult to demonstrate in chronically detached atrophic retinas.
取自3例急性视网膜坏死综合征患者的组织用于病理检查。在2例患者的视网膜活检中发现了属于疱疹病毒科的病毒颗粒，其中1例患者存在免疫抑制。尽管切除了大块活检标本，但其中1例患者术后视网膜在20个月内保持附着状态，另1例则保持了3个月。在第3例获得性免疫缺陷综合征患者中，临床病程及死后免疫病理学表现提示为单纯疱疹病毒感染，最初累及视网膜，随后累及视神经、视交叉、视束及中枢神经系统。这些病例表明，与急性视网膜坏死综合征相关的病毒在疾病急性期通过玻璃体切除术和视网膜内活检很容易得到证实，但在长期脱离的萎缩性视网膜中可能难以证实。
