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重度特应性皮炎患者外周血中CD4+CD29+和CD4+CD45RA+辅助性T细胞亚群失衡。

Imbalance of CD4+CD29+ and CD4+CD45RA+ T-helper cell subsets in peripheral blood of patients with severe atopic dermatitis.

作者信息

Jung K, Bittrich A, Klimmek V, Schubert H

机构信息

Klinik und Poliklinik für Hautkrankheiten, Medizinischen Hochschule, Erfurt, Germany.

出版信息

Arch Dermatol Res. 1993;285(3):135-9. doi: 10.1007/BF01112915.

DOI:10.1007/BF01112915
PMID:7684891
Abstract

To determine the proportion of T-helper cell subsets in the peripheral blood we studied 16 patients with mild, moderate and severe atopic dermatitis. Lymphocytes were isolated from heparinized peripheral blood and analysed by two-colour flow cytometry. Patients with severe atopic dermatitis had a decreased CD4+CD29+: CD4+CD45RA+ ratio (p < 0.01). We found a decreased absolute number of CD4+CD29+ cells (p < 0.05) and an increased absolute number of CD4+CD45RA+ cells (p < 0.05) in the peripheral blood. No significant changes in the CD4+CD29+: CD4+CD45RA+ ratio were found in the peripheral blood of patients with clinically mild or moderate atopic dermatitis.

摘要

为了确定外周血中辅助性T细胞亚群的比例，我们研究了16例轻度、中度和重度特应性皮炎患者。从肝素化外周血中分离淋巴细胞，并通过双色流式细胞术进行分析。重度特应性皮炎患者的CD4+CD29+:CD4+CD45RA+比值降低（p<0.01）。我们发现外周血中CD4+CD29+细胞的绝对数量减少（p<0.05），而CD4+CD45RA+细胞的绝对数量增加（p<0.05）。临床轻度或中度特应性皮炎患者的外周血中CD4+CD29+:CD4+CD45RA+比值未发现显著变化。

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Defective monocyte and polymorphonuclear leukocyte chemotaxis and clinical characteristics in atopic dermatitis.特应性皮炎中单核细胞和多形核白细胞趋化功能缺陷及临床特征
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Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody.进行性多发性硬化症中抑制诱导性T细胞亚群的选择性丧失。用抗2H4单克隆抗体进行分析。
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