Departments of Clinical Studies (Giraldo, Carballo, Tran, Valverde, Gomez) and Population Medicine (Serrenho, Renaud), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
Can Vet J. 2023 Nov;64(11):1044-1050.
Metabolic acidosis (MA) is the most common acid-base disorder reported in horses with colitis but its association with survival is yet to be determined.
Investigate the types of MA in horses with colitis to determine effects of various anions on fatality rates.
We studied 158 horses with colitis. Horses were classified into 4 groups depending on the anion contributing to MA: i) no MA, ii) lactic acidosis (LA), iii) unmeasured strong ion (USI) acidosis, and iv) hyperchloremic acidosis (HA).
Sixty percent (95/158) of horses had no MA, 22% (34/158) had LA, 12% (19/158) had HA, and 6% (10/158) had USI acidosis. The fatality rate of horses without MA was 20% (20/95), whereas the rates for those with LA, USI, and HA were 53% (18/34), 30% (3/10), and 16% (3/19), respectively. Horses with LA were more likely to die or be euthanized than horses without MA (OR: 4.2, 95% CI: 1.83 to 9.72, < 0.001) and HA (OR: 5.9, 95% CI: 1.47 to 24.4, < 0.01).
Lactic acidosis was the most common type of MA in horses with colitis, and it was associated with non-survival.
代谢性酸中毒（MA）是结肠炎马最常见的酸碱紊乱，但它与存活率的关系尚未确定。
研究结肠炎马的 MA 类型，确定各种阴离子对死亡率的影响。
我们研究了 158 例结肠炎马。根据导致 MA 的阴离子，将马分为 4 组：i）无 MA，ii）乳酸酸中毒（LA），iii）未测量的强离子（USI）酸中毒，和 iv）高氯血症酸中毒（HA）。
60%（95/158）的马没有 MA，22%（34/158）有 LA，12%（19/158）有 HA，6%（10/158）有 USI 酸中毒。无 MA 的马死亡率为 20%（20/95），而 LA、USI 和 HA 的死亡率分别为 53%（18/34）、30%（3/10）和 16%（3/19）。患有 LA 的马比没有 MA 的马（OR：4.2，95%CI：1.83 至 9.72，<0.001）和 HA（OR：5.9，95%CI：1.47 至 24.4，<0.01）更有可能死亡或被安乐死。
乳酸酸中毒是结肠炎马最常见的 MA 类型，与非生存相关。
