Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical & Technical Sciences (SIMATS), Saveetha Nagar, Thandalam, Chennai 602105, Tamil Nadu, India.
Department of Applied Chemistry, Sri Venkateswara College of Engineering, Pennalur, Sriperumbudur 602117, Tamil Nadu, India.
Int J Biol Macromol. 2024 Jan;254(Pt 2):127904. doi: 10.1016/j.ijbiomac.2023.127904. Epub 2023 Nov 6.
Nanomaterials are emerging facts used to deliver therapeutic agents in living systems. Nanotechnology is used as a compliment by implementing different kinds of nanotechnological applications such as nano-porous structures, functionalized nanomaterials, quantum dots, carbon nanomaterials, and polymeric nanostructures. The applications are in the initial stage, which led to achieving several diagnoses and therapy in clinical practice. This review conveys the importance of nanomaterials in post-genomic employment, which includes the design of immunosensors, immune assays, and drug delivery. In this view, genomics is a molecular tool containing large databases that are useful in choosing an apt molecular inhibitor such as drug, ligand and antibody target in the drug delivery process. This study identifies the expression of genes and proteins in analysis and classification of diseases. Experimentally, the study analyses the design of a disease model. In particular, drug delivery is a boon area to treat cancer. The identified drugs enter different phase trails (Trails I, II, and III). The genomic information conveys more essential entities to the phase I trials and helps to move further for other trails such as trails-II and III. In such cases, the biomarkers play a crucial role by monitoring the unique pathological process. Genetic engineering with recombinant DNA techniques can be employed to develop genetically engineered disease models. Delivering drugs in a specific area is one of the challenging issues achieved using nanoparticles. Therefore, genomics is considered as a vast molecular tool to identify drugs in personalized medicine for cancer therapy.
纳米材料是新兴的事实，用于在生命系统中输送治疗剂。纳米技术被用作补充，通过实施不同类型的纳米技术应用，如纳米多孔结构、功能化纳米材料、量子点、碳纳米材料和聚合物纳米结构。这些应用处于初始阶段，已经在临床实践中实现了几种诊断和治疗。本综述传达了纳米材料在后基因组学应用中的重要性，包括免疫传感器、免疫分析和药物输送的设计。在这种观点中，基因组学是一种分子工具，包含了大型数据库，这些数据库在药物输送过程中选择合适的分子抑制剂（如药物、配体和抗体靶标）方面非常有用。本研究在疾病的分析和分类中识别基因和蛋白质的表达。从实验上分析疾病模型的设计。特别是，药物输送是治疗癌症的一个福音领域。已鉴定的药物进入不同的阶段试验（试验 I、II 和 III）。基因组信息为 I 期试验传达了更多的重要实体，并有助于进一步进行 II 期和 III 期等其他试验。在这种情况下，生物标志物通过监测独特的病理过程起着至关重要的作用。可以使用重组 DNA 技术进行基因工程来开发基因工程疾病模型。使用纳米颗粒在特定区域输送药物是一个具有挑战性的问题。因此，基因组学被认为是一种广泛的分子工具，可用于癌症治疗的个性化医学中识别药物。
