Department of Microbial Drugs, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), Partner Site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
Department of Biochemistry, Egerton University, P.O. BOX 536, Njoro 20115, Kenya.
Molecules. 2018 Feb 9;23(2):369. doi: 10.3390/molecules23020369.
A mycelial culture of the Kenyan basidiomycete was fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes -, for which we propose the trivial name aethiopinolones A-E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities.
肯尼亚担子菌的菌丝体在大米上发酵，然后用甲醇提取培养物。随后对其粗提取物进行高效液相色谱分析和制备色谱分离，得到了五种以前未描述过的孕烯醇酮型三萜类化合物——，我们将其命名为埃塞俄比亚醇酮 A-E。通过广泛的 1D 和 2D-NMR 以及高分辨率质谱数据分析确定了埃塞俄比亚醇酮的化学结构。这些化合物对各种人类癌细胞系表现出中等的细胞毒性，但没有表现出显著的杀线虫和抗菌活性。
