病例报告：猴咬伤后单纯疱疹病毒 B 型的迟发性再激活：一例严重脑膜脑炎。
Case Report: Late Reactivation of Herpes B Virus After a Monkey Bite: A Case of Severe Meningoencephalitis.
机构信息
Intensive Care Unit, Clinique Saint-Pierre, Ottignies, Belgium.
Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
出版信息
Am J Trop Med Hyg. 2023 Oct 16;109(6):1277-1281. doi: 10.4269/ajtmh.23-0253. Print 2023 Dec 6.
Macacine alphaherpesvirus 1, also known as herpes B virus (BV), is an alphaherpesvirus endemic to several macaque species, capable of causing zoonotic infections in humans, with high mortality rates. Evidence of reactivation in humans has rarely been reported. Here we depict a case of BV reactivation after 54 years, leading to severe meningoencephalitis. This case supports the use of antiviral prophylaxis in patients surviving a confirmed BV central nervous system infection. We sequenced DNA from BV obtained from the patient's cerebrospinal fluid. Phylogenetic analysis showed significant divergence in the clustering of this particular BV strain compared with other known BVs. Therefore, additional efforts are needed to obtain a broader sequence landscape from BVs circulating in monkeys.
猴疱疹病毒 1 型，也称疱疹 B 病毒（BV），是几种猕猴属特有α疱疹病毒，可致人类发生人畜共患病感染，病死率高。人类病毒再激活的证据罕有报道。本研究报道了一例 54 年后的再激活病例，导致严重的脑膜脑炎。该病例支持对确诊中枢神经系统感染 BV 的患者进行抗病毒预防。我们对从患者脑脊液中分离的 BV 进行了 DNA 测序。系统进化分析显示，与其他已知的 BV 相比，该特定 BV 株的聚类存在显著差异。因此，需要进一步努力从猴群中循环的 BV 中获取更广泛的序列景观。
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