Pérez-Ferreiro María, M Abelairas Adrián, Criado Alejandro, Gómez I Jénnifer, Mosquera Jesús
CICA-Centro Interdisciplinar de Química e Bioloxía, Universidade da Coruña, Rúa as Carballeiras, 15071 A Coruña, Spain.
Polymers (Basel). 2023 Nov 9;15(22):4369. doi: 10.3390/polym15224369.
Dendrimers constitute a distinctive category of synthetic materials that bear resemblance to proteins in various aspects, such as discrete structural organization, globular morphology, and nanoscale dimensions. Remarkably, these attributes coexist with the capacity for facile large-scale production. Due to these advantages, the realm of dendrimers has undergone substantial advancement since their inception in the 1980s. Numerous reviews have been dedicated to elucidating this subject comprehensively, delving into the properties and applications of quintessential dendrimer varieties like PAMAM, PPI, and others. Nevertheless, the contemporary landscape of dendrimers transcends these early paradigms, witnessing the emergence of a diverse array of novel dendritic architectures in recent years. In this review, we aim to present a comprehensive panorama of the expansive domain of dendrimers. As such, our focus lies in discussing the key attributes and applications of the predominant types of dendrimers existing today. We will commence with the conventional variants and progressively delve into the more pioneering ones, including Janus, supramolecular, shape-persistent, and rotaxane dendrimers.
树枝状大分子是一类独特的合成材料,在各个方面与蛋白质相似,例如离散的结构组织、球状形态和纳米级尺寸。值得注意的是,这些特性与大规模生产的便利性并存。由于这些优势,自20世纪80年代诞生以来,树枝状大分子领域取得了长足的进步。许多综述致力于全面阐明这一主题,深入探讨典型树枝状大分子品种(如PAMAM、PPI等)的性质和应用。然而,树枝状大分子的当代格局超越了这些早期范式,近年来出现了各种各样新颖的树枝状结构。在这篇综述中,我们旨在全面呈现树枝状大分子广阔领域的全景。因此,我们的重点在于讨论当今存在的主要类型树枝状大分子的关键特性和应用。我们将从传统变体开始,逐步深入探讨更具开创性的类型,包括Janus树枝状大分子、超分子树枝状大分子、形状持久树枝状大分子和轮烷树枝状大分子。
Polymers (Basel). 2023-11-9
Acc Chem Res. 2021-11-2
Pharmaceutics. 2023-2-9
Acc Chem Res. 2014-4-29
Hell J Nucl Med. 2019
Molecules. 2023-7-20
Mol Pharm. 2012-5-4
Top Curr Chem. 2003
Medicine (Baltimore). 2025-8-15
Pharmaceutics. 2025-7-18
Drug Deliv Transl Res. 2025-6-14
Nanomedicine (Lond). 2025-6
Tissue Eng Regen Med. 2025-3-8
J Am Chem Soc. 1997-6-18
Molecules. 2023-7-20
Pharmaceutics. 2023-2-9
Chem Commun (Camb). 2022-8-4
Biomacromolecules. 2022-7-11