Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA.
USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA.
Nat Biomed Eng. 2024 Jun;8(6):712-725. doi: 10.1038/s41551-023-01149-4. Epub 2023 Nov 30.
Techniques for imaging haemodynamics use ionizing radiation or contrast agents or are limited by imaging depth (within approximately 1 mm), complex and expensive data-acquisition systems, or low imaging speeds, system complexity or cost. Here we show that ultrafast volumetric photoacoustic imaging of haemodynamics in the human body at up to 1 kHz can be achieved using a single laser pulse and a single element functioning as 6,400 virtual detectors. The technique, which does not require recalibration for different objects or during long-term operation, enables the longitudinal volumetric imaging of haemodynamics in vasculature a few millimetres below the skin's surface. We demonstrate this technique in vessels in the feet of healthy human volunteers by capturing haemodynamic changes in response to vascular occlusion. Single-shot volumetric photoacoustic imaging using a single-element detector may facilitate the early detection and monitoring of peripheral vascular diseases and may be advantageous for use in biometrics and point-of-care testing.
我们展示了一种新技术，它可使用单个激光脉冲和单个元件（充当 6400 个虚拟探测器），在人体中以高达 1kHz 的频率进行超快速容积式光声血流成像。该技术无需针对不同物体或在长期运行期间进行重新校准，能够对皮肤表面以下几毫米的脉管系统中的血流动力学进行纵向容积式成像。我们通过捕获血管阻塞时的血流动力学变化，在健康志愿者脚部的血管中证明了该技术。使用单元素探测器的单次容积式光声成像，可能有助于早期检测和监测外周血管疾病，并且在生物识别和即时检测中可能具有优势。
