Bone Marrow Transplantation Center of the First Affiliated Hospital, and Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Liangzhu Laboratory, Zhejiang University, Hangzhou, Zhejiang, 311121, China.
Adv Sci (Weinh). 2024 Feb;11(8):e2305449. doi: 10.1002/advs.202305449. Epub 2023 Dec 25.
Recent advancements in single-cell technologies have led to rapid developments in the construction of cell atlases. These atlases have the potential to provide detailed information about every cell type in different organisms, enabling the characterization of cellular diversity at the single-cell level. Global efforts in developing comprehensive cell atlases have profound implications for both basic research and clinical applications. This review provides a broad overview of the cellular diversity and dynamics across various biological systems. In addition, the incorporation of machine learning techniques into cell atlas analyses opens up exciting prospects for the field of integrative biology.
单细胞技术的最新进展推动了细胞图谱构建的快速发展。这些图谱有可能提供不同生物体中每个细胞类型的详细信息,从而实现单细胞水平的细胞多样性特征描述。全球范围内开发全面细胞图谱的努力对基础研究和临床应用都具有深远的意义。本综述广泛概述了各种生物系统中的细胞多样性和动态。此外,将机器学习技术纳入细胞图谱分析为整合生物学领域开辟了令人兴奋的前景。