Lima Rodrigo A, Condominas Elena, Sanchez-Niubo Albert, Olaya Beatriz, Koyanagi Ai, de Miquel Carlota, Haro Josep Maria
Research, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, Dr Antoni Pujadas 42, 08830, Sant Boi de Llobregat, Spain.
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Sports Med Open. 2024 Jan 3;10(1):1. doi: 10.1186/s40798-023-00664-7.
To which extent physical activity is associated with depression independent of older adults' physical and cognitive functioning is largely unknown. This cohort study using harmonised data by the EU Ageing Trajectories of Health: Longitudinal Opportunities and Synergies consortium, including over 20 countries, to evaluate the longitudinal association of physical activity (light-to-moderate or vigorous intensity) with depression in older adults (aged ≥ 50 years).
We evaluated 56,818 participants (light-to-moderate models; 52.7% females, age 50-102 years) and 62,656 participants (vigorous models; 52.7% females, age 50-105 years). Compared to never, light-to-moderate or vigorous physical activity was associated with a lower incidence rate ratio (IRR) of depression (light-to-moderate model: once/week: 0.632, 95% CI 0.602-0.663; twice or more/week: 0.488, 95% CI 0.468-0.510; vigorous model: once/week: 0.652, 95% CI 0.623-0.683; twice or more/week: 0.591, 95% CI 0.566-0.616). Physical activity remained associated with depression after adjustment for the healthy ageing scale, which is a scale that incorporated 41 items of physical and cognitive functioning (light-to-moderate model: once/week: 0.787, 95% CI 0.752-0.824; twice or more/week: 0.711, 95% CI 0.682-0.742; vigorous model: once/week: 0.828, 95% CI 0.792-0.866; twice or more/week: 0.820, 95% CI 0.786-0.856).
Physical activity, of any intensity and weekly frequency, was a strong protective factor against depression, independent of physical and mental functioning. Health policies could stimulate the incorporation of lower physical activity intensity to protect against depression, which might be more feasible at the population level.
体力活动与抑郁症之间的关联程度，在多大程度上独立于老年人的身体和认知功能，目前尚不清楚。这项队列研究使用了欧盟健康老龄化轨迹：纵向机会与协同效应联盟（包括20多个国家）的协调数据，以评估体力活动（轻度至中度或剧烈强度）与老年人（年龄≥50岁）抑郁症之间的纵向关联。
我们评估了56818名参与者（轻度至中度模型；52.7%为女性，年龄50 - 102岁）和62656名参与者（剧烈模型；52.7%为女性，年龄50 - 105岁）。与从不进行体力活动相比，轻度至中度或剧烈体力活动与较低的抑郁症发病率比（IRR）相关（轻度至中度模型：每周一次：0.632，95%置信区间0.602 - 0.663；每周两次或更多次：0.488，95%置信区间0.468 - 0.510；剧烈模型：每周一次：0.652，95%置信区间0.623 - 0.683；每周两次或更多次：0.591，95%置信区间0.566 - 0.616）。在调整了健康老龄化量表后，体力活动仍与抑郁症相关，该量表包含41项身体和认知功能指标（轻度至中度模型：每周一次：0.787，95%置信区间0.752 - 0.824；每周两次或更多次：0.711，95%置信区间0.682 - 0.742；剧烈模型：每周一次：0.828，95%置信区间0.792 - 0.866；每周两次或更多次：0.820，95%置信区间0.786 - 0.856）。
任何强度和每周频率的体力活动都是预防抑郁症的强大保护因素，独立于身体和心理功能。卫生政策可以鼓励纳入较低强度的体力活动以预防抑郁症，这在人群层面可能更可行。
