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腹主动脉瘤患者的晚期生存:基于临床症状的选择性心肌血运重建的作用。

Late survival in abdominal aortic aneurysm patients: the role of selective myocardial revascularization on the basis of clinical symptoms.

作者信息

Reigel M M, Hollier L H, Kazmier F J, O'Brien P C, Pairolero P C, Cherry K J, Hallett J W

出版信息

J Vasc Surg. 1987 Feb;5(2):222-7.

PMID:3820399
Abstract

Coronary artery disease is recognized as the major cause of perioperative and late death after abdominal aortic aneurysm (AAA) repair. Routine coronary angiography and prophylactic myocardial revascularization for all significant lesions, regardless of symptoms, have been recommended as a means of reducing this mortality risk. We have advocated a more selective approach in which coronary angiography and myocardial revascularization are performed on the basis of cardiac symptoms. Studies have shown that this selective approach is just as effective as the prophylactic approach in reducing perioperative deaths. To evaluate the effect on late survival of selective myocardial revascularization on the basis of symptoms, we reviewed the preoperative coronary status and course of 485 patients who successfully underwent AAA repair between 1980 and 1985. Late survival was evaluated by means of the Kaplan-Meier method and compared with life expectancy of an age- and sex-matched population. Late survival of the entire group of patients was no different from that of the matched population. Patients with no preoperative evidence of coronary artery disease did significantly better than expected (p = 0.05), whereas those patients with uncorrected or previously bypassed coronary disease had survival no different from that expected. When age was considered as a variable, patients in their 50s and 60s had survival significantly worse than the matched population (p less than 0.001 and p = 0.003, respectively). Patients in their 70s and 80s had survival as good as or better than the matched population, regardless of coronary status.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

冠状动脉疾病被认为是腹主动脉瘤(AAA)修复术后围手术期和晚期死亡的主要原因。对于所有严重病变,无论有无症状,均建议进行常规冠状动脉造影和预防性心肌血运重建,以此作为降低这种死亡风险的一种手段。我们主张采用一种更具选择性的方法,即根据心脏症状进行冠状动脉造影和心肌血运重建。研究表明,这种选择性方法在降低围手术期死亡方面与预防性方法同样有效。为了评估基于症状的选择性心肌血运重建对晚期生存的影响,我们回顾了1980年至1985年间成功接受AAA修复的485例患者的术前冠状动脉状况和病程。通过Kaplan-Meier方法评估晚期生存情况,并与年龄和性别匹配人群的预期寿命进行比较。整个患者组的晚期生存与匹配人群无异。术前无冠状动脉疾病证据的患者的生存情况明显优于预期(p = 0.05),而那些未矫正或先前已行搭桥手术的冠状动脉疾病患者的生存情况与预期无异。将年龄作为一个变量考虑时,50多岁和60多岁的患者的生存情况明显差于匹配人群(分别为p < 0.001和p = 0.003)。70多岁和80多岁的患者,无论冠状动脉状况如何,其生存情况与匹配人群相同或更好。(摘要截短于250字)

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