Ramos de Ascanio Victoria, Liaño-Esteso Gloria, Roldán David, Collazo-Lorduy Teresa, Martínez-Flores Sara, Hernández-Rivas José Ángel, González-Gascón-Y-Marín Isabel
Hematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain.
Radiology Department, Clínica Universidad de Navarra, 28031 Madrid, Spain.
Geriatrics (Basel). 2023 Dec 28;9(1):4. doi: 10.3390/geriatrics9010004.
(1) Background: Gradenigo's Syndrome (GS) is a rare complication of acute otitis media characterized by the triad of diplopia, otitis, and facial pain. The widespread use of antibiotics has significantly reduced its occurrence. (2) Case summary: We present the case of an elderly patient with T-cell lymphoma who developed neurological deficits resembling GS. The patient was ultimately diagnosed with invasive sinus aspergillosis. The diagnostic process was challenging due to the atypical clinical presentation and the lack of specific imaging findings. A biopsy was the most important test for clarifying the diagnosis. (3) Conclusions: The prognosis for this complication is extremely poor without surgery, and the patient died despite adequate antifungal coverage. Therefore, maintaining high clinical suspicion is paramount to avoid adverse outcomes in similar cases, particularly in the geriatric population, wherein this syndrome's occurrence may not be expected.
(1) 背景：Gradenigo综合征（GS）是急性中耳炎的一种罕见并发症，其特征为复视、中耳炎和面部疼痛三联征。抗生素的广泛使用已显著降低了其发生率。(2) 病例摘要：我们报告了一例老年T细胞淋巴瘤患者，其出现了类似GS的神经功能缺损。该患者最终被诊断为侵袭性鼻窦曲霉菌病。由于临床表现不典型且缺乏特异性影像学表现，诊断过程具有挑战性。活检是明确诊断的最重要检查。(3) 结论：该并发症若不进行手术，预后极差，尽管给予了充分的抗真菌治疗，患者仍死亡。因此，保持高度的临床怀疑对于避免类似病例出现不良后果至关重要，尤其是在老年人群中，因为该综合征在这一人群中可能并不常见。
