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格拉代尼戈综合征:超越复视、面部疼痛和耳漏的经典三联征。

Gradenigo's Syndrome: Beyond the Classical Triad of Diplopia, Facial Pain and Otorrhea.

作者信息

Pedroso José Luiz, de Aquino Camila Catherine Henriques, Abrahão Agessandro, de Oliveira Ricardo Araújo, Pinto Lauro Figueira, Bezerra Márcio Luis Escórcio, Gonçalves Silva Antonio Beuttenmuller, de Macedo Francisca Delanie Bulcão, de Melo Mendes Ana Valéria, Barsottini Orlando Graziani Povoas

机构信息

Departments of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.

出版信息

Case Rep Neurol. 2011 Feb 15;3(1):45-7. doi: 10.1159/000324179.

DOI:10.1159/000324179
PMID:21490711
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3072192/
Abstract

We report a case of a non-Hodgkin's lymphoma in a young woman presenting with an abdominal mass and an unusual instance of cranial nerve palsies mimicking Gradenigo's syndrome. This condition is characterized by a triad of otorrhea, facial pain and diplopia, related to otitis media in the pre-antibiotic era. Incomplete and atypical clinical features of Gradenigo's syndrome have been described and noninfectious causes may mimic this condition. Careful clinical history and physical examination, including neuroimaging, are necessary to make a differential diagnosis.

摘要

我们报告一例年轻女性非霍奇金淋巴瘤病例,该患者表现为腹部肿块,并出现了罕见的类似Gradenigo综合征的颅神经麻痹。这种情况的特征是耳漏、面部疼痛和复视三联征,在抗生素时代之前与中耳炎有关。已有文献描述了Gradenigo综合征不完整和非典型的临床特征,非感染性原因可能会模仿这种情况。进行鉴别诊断需要详细的临床病史和体格检查,包括神经影像学检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/398d/3072192/db63ea651dbb/crn0003-0045-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/398d/3072192/db63ea651dbb/crn0003-0045-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/398d/3072192/db63ea651dbb/crn0003-0045-f01.jpg

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本文引用的文献

1
Diffusion-weighted MRI identifies petrous apex abscess in Gradenigo syndrome.弥散加权 MRI 可识别 Gradenigo 综合征中的岩尖脓肿。
J Neuroophthalmol. 2010 Mar;30(1):34-6. doi: 10.1097/WNO.0b013e3181c5d0fd.
2
Gradenigo's syndrome and Dorello's canal.格拉代尼戈综合征与多雷洛管
Acta Otorhinolaryngol Ital. 2009 Jun;29(3):169-72.
3
Gradenigo's syndrome presenting as a tumor.表现为肿瘤的Gradenigo综合征。
Cureus. 2024 Jun 24;16(6):e63062. doi: 10.7759/cureus.63062. eCollection 2024 Jun.
4
Challenging Diagnosis of Invasive Sinus Aspergillosis Mimicking Gradenigo's Syndrome in an Elderly Patient with T-Cell Lymphoma.老年T细胞淋巴瘤患者侵袭性鼻窦曲霉菌病酷似Gradenigo综合征的挑战性诊断
Geriatrics (Basel). 2023 Dec 28;9(1):4. doi: 10.3390/geriatrics9010004.
5
Gradenigo's syndrome presenting as IX and X cranial nerve palsy without clinically apparent ear infection: A case report and review of literature.以Ⅸ和Ⅹ颅神经麻痹为表现且无明显耳部感染的Gradenigo综合征:一例病例报告及文献复习
eNeurologicalSci. 2022 Mar 17;27:100397. doi: 10.1016/j.ensci.2022.100397. eCollection 2022 Jun.
6
Steroid-Responsive Gradenigo's Syndrome Mimicking Subdural Hematoma.模仿硬膜下血肿的类固醇反应性Gradenigo综合征
Cureus. 2021 Nov 13;13(11):e19547. doi: 10.7759/cureus.19547. eCollection 2021 Nov.
7
An unusual case of acute otitis media resulting in Gradenigo syndrome: CT and MRI findings.一例导致Gradenigo综合征的罕见急性中耳炎病例:CT和MRI表现
Radiol Case Rep. 2021 Oct 14;16(12):3903-3907. doi: 10.1016/j.radcr.2021.09.026. eCollection 2021 Dec.
8
Gradenigo's Syndrome and Bacterial Meningitis in a Patient with a Petrous Apex Cholesterol Granuloma.岩尖胆固醇肉芽肿患者的Gradenigo综合征与细菌性脑膜炎
Case Rep Infect Dis. 2020 Oct 20;2020:8822053. doi: 10.1155/2020/8822053. eCollection 2020.
9
Gradenigo's syndrome secondary to chronic otitis media on a background of previous radical mastoidectomy: a case report.既往行根治性乳突切除术后继发于慢性中耳炎的Gradenigo综合征:一例报告
J Med Case Rep. 2014 Jun 23;8:217. doi: 10.1186/1752-1947-8-217.
Otolaryngol Head Neck Surg. 2006 Nov;135(5):821-2. doi: 10.1016/j.otohns.2005.03.034.
4
Gradenigo syndrome: a case report and review of a rare complication of otitis media.格拉代尼戈综合征:一例中耳炎罕见并发症的病例报告及文献综述
J Emerg Med. 2004 Oct;27(3):253-6. doi: 10.1016/j.jemermed.2004.03.014.
5
Primary non-Hodgkin's lymphoma of the petrous bone: case report.岩骨原发性非霍奇金淋巴瘤:病例报告
Otolaryngol Head Neck Surg. 2004 Mar;130(3):360-2. doi: 10.1016/j.otohns.2003.08.006.
6
[Gradenigo syndrome as the form of presentation of nasopharyngeal carcinoma].[作为鼻咽癌表现形式的Gradenigo综合征]
Rev Neurol. 2001;32(7):638-40.
7
Gradenigo syndrome as presenting sign of T-cell lymphoma.Gradenigo综合征作为T细胞淋巴瘤的首发症状。
Pediatr Neurol. 1989 Nov-Dec;5(6):377-80. doi: 10.1016/0887-8994(89)90053-2.