青少年慢性关节炎中的贫血：体外血清对正常红细胞生成的抑制作用。
Anaemia in juvenile chronic arthritis: serum inhibition of normal erythropoiesis in vitro.
作者信息
Prouse P J, Harvey A R, Bonner B, Reid C D, Ansell B M, Gumpel M
出版信息
Ann Rheum Dis. 1987 Feb;46(2):127-34. doi: 10.1136/ard.46.2.127.
Abstract
Serum from patients with juvenile chronic arthritis (JCA) was shown to inhibit colony formation by normal erythropoietic progenitor cells cultured in vitro. The inhibition was proportional to the degree of anaemia and to certain indices of activity of the arthritis and systemic disease. It occurred in a dose dependent manner with increasing serum concentration and was independent of previous blood transfusion or administered drugs. Erythropoietic progenitor cells from the bone marrows of anaemic patients with JCA showed normal requirements for accessory cells (T lymphocytes and macrophages) in culture, and autologous accessory cells were not deficient in providing normal growth requirements.
摘要
研究表明，青少年慢性关节炎（JCA）患者的血清可抑制体外培养的正常红细胞生成祖细胞的集落形成。这种抑制作用与贫血程度以及关节炎和全身性疾病的某些活动指标成正比。它随着血清浓度的增加呈剂量依赖性发生，且与既往输血或用药无关。患有JCA的贫血患者骨髓中的红细胞生成祖细胞在培养中对辅助细胞（T淋巴细胞和巨噬细胞）有正常需求，并且自体辅助细胞在提供正常生长需求方面并不缺乏。
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