类风湿性关节炎贫血患者的T淋巴细胞对骨髓红细胞生成的刺激作用
Stimulation of bone marrow erythropoiesis by T lymphocytes of anaemic patients with rheumatoid arthritis.
作者信息
Prouse P J, Bonner B, Gumpel J M, Reid C D
出版信息
Ann Rheum Dis. 1985 Apr;44(4):220-3. doi: 10.1136/ard.44.4.220.
Abstract
An inappropriate response of the bone marrow is implicated in the aetiology of the anaemia of chronic disease complicating rheumatoid arthritis. T lymphocyte subsets have been shown to inhibit early erythroid development in vitro in association with some cases of bone marrow failure, and an expanded peripheral blood pool of these cells is reported in rheumatoid arthritis. We have studied the role of peripheral blood T lymphocytes in erythroid bone marrow culture from seven normal volunteers and nine anaemic patients with rheumatoid arthritis and found comparable stimulation of growth in both groups.
摘要
骨髓的不适当反应与类风湿关节炎并发的慢性病贫血的病因有关。在一些骨髓衰竭病例中，T淋巴细胞亚群已被证明在体外可抑制早期红系发育，并且在类风湿关节炎患者中报告了这些细胞在外周血中的数量增加。我们研究了七名正常志愿者和九名类风湿关节炎贫血患者外周血T淋巴细胞在红系骨髓培养中的作用，发现两组的生长刺激作用相当。
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