Cabrera-Rubio Raúl, Pickett-Nairne Kaci, González-Solares Sonia, Collado Maria Carmen, Venter Carina
Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Agustin Escardino 7, 46980 Paterna, Spain.
Department of Pediatrics, University of Colorado School of Medicine, University of Colorado, Aurora, CO 80045, USA.
Nutrients. 2024 Jan 20;16(2):314. doi: 10.3390/nu16020314.
Maternal diet during pregnancy may play a role in infant health outcomes via the maternal microbiota. We assessed the association of the maternal diet index for the Mediterranean area (MDI-med) with infant gut microbiota at 1 month of life. The MAMI study is a longitudinal birth cohort in the Mediterranean area. In this work, a cross-sectional study, including 120 mother-infant dyads with available maternal diet and infant microbiota at 1-month-old data, was undertaken. The MDI developed in the US (MDI-US) was adapted for the MAMI cohort (MDI-med). Stratification based on extreme values resulted (22 in the "lower" MDI-med group and 23 in the "upper" group from the mean). Relative microbial abundances and alpha (microbial richness and diversity indexes) and beta diversity (Bray-Curtis distance matrix) were compared between the groups. Higher maternal daily vegetable intake and lower red meat intake were the characteristics of the "upper" MDI-med group. Significantly lower microbial diversity (Shannon and InvSimpson index ( 0.01)), but no changes in richness (Chao1 index) nor in beta-diversity, using Bray-Curtis distance, were observed in the "upper" group, compared to the "lower" MDI-med group. A higher relative abundance of the genus (Actinomycetota phylum) was associated with maternal daily vegetable and yogurt intake. Reduced infant microbial diversity at 1 month of age was associated with "upper" MDI-med scores. Higher maternal intakes of vegetables and yogurt were associated with higher relative abundances of the genus in the infant gut. Further studies are needed to understand the link between pregnancy diet, infant microbiota, and health outcomes.
孕期母亲的饮食可能通过母体微生物群对婴儿的健康结果产生影响。我们评估了地中海地区母亲饮食指数（MDI-med）与婴儿1月龄时肠道微生物群的关联。MAMI研究是地中海地区的一项纵向出生队列研究。在这项横断面研究中，纳入了120对母婴二元组，这些母婴二元组有母亲饮食和婴儿1月龄时微生物群的可用数据。美国开发的MDI（MDI-US）被改编用于MAMI队列（MDI-med）。根据极端值进行分层（平均分为“较低”MDI-med组22例和“较高”组23例）。比较了两组之间的相对微生物丰度、α（微生物丰富度和多样性指数）和β多样性（Bray-Curtis距离矩阵）。“较高”MDI-med组的特征是母亲每日蔬菜摄入量较高和红肉摄入量较低。与“较低”MDI-med组相比，“较高”组的微生物多样性显著降低（香农和逆辛普森指数（P<0.01）），但丰富度（Chao1指数）和使用Bray-Curtis距离的β多样性没有变化。放线菌门的一个属的相对丰度较高与母亲每日蔬菜和酸奶摄入量有关。1月龄婴儿微生物多样性降低与“较高”MDI-med评分有关。母亲较高的蔬菜和酸奶摄入量与婴儿肠道中该属的相对丰度较高有关。需要进一步研究以了解孕期饮食、婴儿微生物群和健康结果之间的联系。
