Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Semin Respir Crit Care Med. 2024 Feb;45(1):3-20. doi: 10.1055/s-0043-1777259. Epub 2024 Jan 29.
The filamentous fungus causes a wide spectrum of diseases in the human lung, with being the most pathogenic and allergenic subspecies. The broad range of clinical syndromes that can develop from the presence of in the respiratory tract is determined by the interaction between host and pathogen. In this review, an oversight of the different clinical entities of pulmonary aspergillosis is given, categorized by their main pathophysiological mechanisms. The underlying immune processes are discussed, and the main clinical, radiological, biochemical, microbiological, and histopathological findings are summarized.
丝状真菌 在人类肺部引起广泛的疾病, 是最具致病性和过敏性的亚种。呼吸道中存在 的情况下可能发展出的广泛临床综合征是由宿主和病原体相互作用决定的。在这篇综述中,根据其主要的病理生理机制,对肺部曲霉菌病的不同临床实体进行了概述。讨论了潜在的免疫过程,并总结了主要的临床、放射学、生化、微生物学和组织病理学发现。