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白内障人群中 IOLMaster 700 生物测量的可重复性。

Repeatability of biometric measures from the IOLMaster 700 in a cataractous population.

机构信息

Department of Experimental Ophthalmology, Saarland University, Homburg/Saar, Germany.

Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Aniridia Research, Saarland University, Homburg/Saar, Germany.

出版信息

PLoS One. 2024 Feb 8;19(2):e0297869. doi: 10.1371/journal.pone.0297869. eCollection 2024.

Abstract

PURPOSE

The purpose of this study was to investigate the repeatability of biometric measures and also to assess the interactions between the uncertainties in these measures for use in an error propagation model, using data from a large patient cohort.

METHODS

In this cross-sectional non-randomised study we evaluated a dataset containing 3379 IOLMaster 700 biometric measurements taken prior to cataract surgery. Only complete scans with at least 3 successful measurements for each eye performed on the same day were considered. The mean (Mean) and standard deviations (SD) for each sequence of measurements were derived and analysed. Correlations between the uncertainties were assessed using Spearman rank correlations.

RESULTS

In the dataset with 677 eyes matching the inclusion criteria, the within subject standard deviation and repeatability for all parameters match previously published data. The SD of the axial length (AL) increased with the Mean AL, but there was no noticeable dependency of the SD of any of the other parameters on their corresponding Mean value. The SDs of the parameters are not independent of one another, and in particular we observe correlations between those for AL, anterior chamber depth, aqueous depth, lens thickness and corneal thickness.

CONCLUSIONS

The SD change over Mean for AL measurement and the correlations between the uncertainties of several biometric parameters mean that a simple Gaussian error propagation model cannot be used to derive the effect of biometric uncertainties on the predicted intraocular lens power and refraction after cataract surgery.

摘要

目的

本研究旨在调查生物测量的可重复性,并评估这些测量不确定性之间的相互作用,以便在误差传播模型中使用,该模型基于一个大型患者队列的数据。

方法

在这项横断面非随机研究中,我们评估了一个包含 3379 例白内障术前 IOLMaster 700 生物测量数据的数据集。仅考虑了同一天对每只眼睛进行至少 3 次成功测量的完整扫描。对每个测量序列的均值(Mean)和标准差(SD)进行了推导和分析。使用 Spearman 秩相关评估不确定性之间的相关性。

结果

在符合纳入标准的 677 只眼中的数据集内,所有参数的个体内标准差和可重复性与先前发表的数据相匹配。眼轴(AL)的 SD 随 Mean AL 增加而增加,但任何其他参数的 SD 与其相应的 Mean 值之间没有明显的依赖关系。参数的 SD 彼此不独立,特别是我们观察到 AL、前房深度、房水深度、晶状体厚度和角膜厚度之间的参数之间存在相关性。

结论

AL 测量的 Mean 变化和几个生物测量参数的不确定性之间的相关性意味着,简单的高斯误差传播模型不能用于推导生物测量不确定性对白内障手术后预测的人工晶状体屈光力和折射的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba1/10852222/f05cd2667f1b/pone.0297869.g001.jpg

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