Department of Ophthalmology, the Affiliated Hospital of Yunnan University, Kunming, China.
Department of Ophthalmology, The Second People's Hospital of Yunnan Province, Kunming, China.
BMC Ophthalmol. 2024 Feb 12;24(1):59. doi: 10.1186/s12886-024-03342-8.
Several studies have previously reported the normal values of corneal volume (CV) in various populations, whereas little is known about the CV distribution in healthy young Chinese adults. Our study aimed to investigate the distribution of CV and its relationships with other ocular biometric parameters among healthy young Chinese adults.
A total of 1645 eyes from 1645 students at Dali University in Yunnan Province, China, were analyzed. Pentacam was used to measure CV. Central corneal thickness (CCT) and biomechanically corrected intraocular pressure (bIOP) were evaluated by Corvis-ST. Other biometrical parameters, including axial length (AL), keratometry, and white-to-white (WTW) distance, were measured using IOL Master.
The mean age of the study population was 19.01 ± 0.92 years, and 68.81% of them were women. The CV was normally distributed in the whole sample, with a mean value of 61.23 ± 3.22 mm. CV and CCT were significantly smaller in the Yi ethnic group than in the Han ethnic group (p < 0.01). CCT (coefficient: 0.085; p < 0.001) and keratometry (coefficient: 0.422; p < 0.001) were positively correlated with CV, while AL (coefficient: -0.204; p < 0.001), WTW distance (coefficient: -0.236; p < 0.001) and bIOP (coefficient: -0.06; p < 0.001) were inversely associated with CV.
Our study provides an age-specific distribution of CV among healthy young Chinese adults. CCT, keratometry, AL, WTW distance and bIOP were important factors associated with CV.
先前有几项研究报告了不同人群的角膜容积（CV）正常值，而对于健康的中国年轻成年人的 CV 分布知之甚少。我们的研究旨在调查健康的中国年轻成年人的 CV 分布及其与其他眼部生物测量参数的关系。
分析了来自中国云南省大理大学的 1645 名学生的 1645 只眼。使用 Pentacam 测量 CV。使用 Corvis-ST 评估中央角膜厚度（CCT）和生物力学校正眼压（bIOP）。使用 IOL Master 测量其他生物测量参数，包括眼轴长度（AL）、角膜曲率和白到白（WTW）距离。
研究人群的平均年龄为 19.01±0.92 岁，其中 68.81%为女性。整个样本中 CV 呈正态分布，平均值为 61.23±3.22mm。与汉族相比，彝族的 CV 和 CCT 较小（p<0.01）。CCT（系数：0.085；p<0.001）和角膜曲率（系数：0.422；p<0.001）与 CV 呈正相关，而 AL（系数：-0.204；p<0.001）、WTW 距离（系数：-0.236；p<0.001）和 bIOP（系数：-0.06；p<0.001）与 CV 呈负相关。
我们的研究提供了健康的中国年轻成年人中 CV 的年龄特异性分布。CCT、角膜曲率、AL、WTW 距离和 bIOP 是与 CV 相关的重要因素。
