Alimoradi Zainab, Jafari Elahe, Roshandel Zahra, Potenza Marc N, Lin Chung-Ying, Pakpour Amir H
Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, 3419759811.
Department of Odontology and Oral Health Science, School of Health and Welfare, Jönköping University, Jönköping, Sweden.
BDJ Open. 2024 Feb 13;10(1):9. doi: 10.1038/s41405-024-00191-x.
The present systematic review aimed to investigate how oral health related quality of life (OHQOL) associates with anxiety and depression. The study protocol was registered prospectively in the PROSPERO database (CRD42023389372).
Studies investigating associations between OHQOL and depression and/or anxiety were included. Fisher's Z scores were used to summarize associations between OHQOL and depression/anxiety. Funnel plots and Begg's Tests were used to assess publication bias. Meta-regression was conducted to examine potential moderator effects in the associations. Academic databases including the ISI Web of Knowledge, Scopus, ProQuest and PubMed were systematically searched. The quality of included studies was checked with the Newcastle Ottawa Scale (NOS).
All 15 included studies were cross-sectional (14,419 participants from nine countries; mean age=43.74 years). The pooled estimates showed weak associations between OHQOL and depression (Fisher's z-score of 0.26 [95% CI = 0.17, 0.35; I = 96.2%; τ = 0.03]) and anxiety (Fisher's z-score of 0.22 [95% CI = 0.001, 0.43; I = 97.9%; τ = 0.06]). No severe problems in methodology quality, publication biases, or moderator effects were observed.
Both depression and anxiety were weakly associated with individuals' OHQOL. Although the synthesized associations were not strong, they were significant, indicating that depression and anxiety are potential factors influencing individuals' OHQOL.
本系统评价旨在研究口腔健康相关生活质量（OHQOL）与焦虑和抑郁之间的关联。该研究方案已前瞻性注册于PROSPERO数据库（CRD42023389372）。
纳入研究OHQOL与抑郁和/或焦虑之间关联的研究。采用Fisher Z分数总结OHQOL与抑郁/焦虑之间的关联。采用漏斗图和Begg检验评估发表偏倚。进行Meta回归以检验关联中的潜在调节效应。系统检索了包括ISI Web of Knowledge、Scopus、ProQuest和PubMed在内的学术数据库。采用纽卡斯尔渥太华量表（NOS）检查纳入研究的质量。
所有15项纳入研究均为横断面研究（来自9个国家的14419名参与者；平均年龄=43.74岁）。汇总估计显示OHQOL与抑郁之间存在弱关联（Fisher z分数为0.26 [95%CI = 0.17, 0.35；I = 96.2%；τ = 0.03]）以及与焦虑之间存在弱关联（Fisher z分数为0.22 [95%CI = 0.001, 0.43；I = 97.9%；τ = 0.06]）。未观察到方法学质量、发表偏倚或调节效应方面的严重问题。
抑郁和焦虑均与个体的OHQOL存在弱关联。尽管综合关联不强，但具有显著性，表明抑郁和焦虑是影响个体OHQOL的潜在因素。
