Griffin J A, Griffin F M
J Exp Med. 1979 Sep 19;150(3):653-75. doi: 10.1084/jem.150.3.653.
The function of complement receptors of mouse peritoneal macrophages was converted in vitro from mediating only attachment of macrophage complement receptor function was achieved by treating freshly explanted macrophages with supernates from cultures containing T lymphocytes and appropriately triggered macrophages. Fc receptor-mediated phagocyctosis by macrophages was required for the production of active supernates, for neither ingestion via the cells' complement receptors nor ingestion via nonimmunologic means was a sufficient stimulus for the macrophages' participation in the generation of supernatant activity. Fc receptor-triggered macrophages interacted by a contact dependent, but histocompatibility independent, mechanism with T lymphocytes, thereby signalling the lymphocytes to elaborate the active product. The possible significance of enhanced macrophage complement receptor function in inflammation, host defense against microbial pathogens, immune complex disease, and neoplasia is discussed.
小鼠腹腔巨噬细胞补体受体的功能在体外发生了转变，从仅介导巨噬细胞补体受体功能的附着转变为通过用含有T淋巴细胞和适当触发的巨噬细胞的培养上清液处理新鲜分离的巨噬细胞来实现。巨噬细胞通过Fc受体介导的吞噬作用是产生活性上清液所必需的，因为通过细胞补体受体的摄取或通过非免疫方式的摄取都不足以刺激巨噬细胞参与上清液活性的产生。Fc受体触发的巨噬细胞通过一种接触依赖性但组织相容性非依赖性的机制与T淋巴细胞相互作用，从而向淋巴细胞发出信号以产生活性产物。文中讨论了增强的巨噬细胞补体受体功能在炎症、宿主抵御微生物病原体、免疫复合物疾病和肿瘤形成中的可能意义。
