Bao Han, Zhang Yanyuan, Xin He, Gao Ye, Hou Yan, Yue Guichu, Wang Nü, Wang Yaqiong, Li Chun, Liu Fuwei, Zhao Yong, Kong Liang
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing 100191, China.
ACS Omega. 2024 Feb 9;9(7):7609-7620. doi: 10.1021/acsomega.3c06628. eCollection 2024 Feb 20.
The process of reconstructing an arterial graft is a complex and dynamic process that is subject to the influence of various mechanical factors, including tissue regeneration and blood pressure. The attainment of favorable remodeling outcomes is contingent upon the biocompatibility and biomechanical properties of the arterial graft. A promising strategy involves the emulation of the three-layer structure of the native artery, wherein the inner layer is composed of polycaprolactone (PCL) fibers aligned with blood flow, exhibiting excellent biocompatibility that fosters endothelial cell growth and effectively prevents platelet adhesion. The middle layer, consisting of PCL and polyurethane (PU), offers mechanical support and stability by forming a contractile smooth muscle ring and antiexpansion PU network. The outer layer, composed of PCL fibers with an irregular arrangement, promotes the growth of nerves and pericytes for long-term vascular function. Prioritizing the reconstruction of the inner and outer layers establishes a stable environment for intermediate smooth muscle growth. Our three-layer arterial graft is designed to provide the blood vessel with mechanical support and stability through nondegradable PU, while the incorporation of degradable PCL generates potential spaces for tissue ingrowth, thereby transforming our graft into a living implant.
动脉移植物的重建过程是一个复杂且动态的过程，会受到各种机械因素的影响，包括组织再生和血压。获得良好的重塑结果取决于动脉移植物的生物相容性和生物力学特性。一种有前景的策略是模仿天然动脉的三层结构，其中内层由与血流方向一致的聚己内酯（PCL）纤维组成，具有出色的生物相容性，可促进内皮细胞生长并有效防止血小板粘附。中层由PCL和聚氨酯（PU）组成，通过形成收缩性平滑肌环和抗扩张PU网络提供机械支撑和稳定性。外层由排列不规则的PCL纤维组成，促进神经和周细胞的生长以实现长期血管功能。优先重建内层和外层为中间平滑肌生长建立了稳定的环境。我们的三层动脉移植物旨在通过不可降解的PU为血管提供机械支撑和稳定性，而可降解PCL的加入为组织向内生长创造了潜在空间，从而将我们的移植物转变为活体植入物。
