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新冠病毒感染后疲劳性疾病的发病率估计和预测因素。

Estimates of Incidence and Predictors of Fatiguing Illness after SARS-CoV-2 Infection.

出版信息

Emerg Infect Dis. 2024 Mar;30(3):539-547. doi: 10.3201/eid3003.231194.

DOI:10.3201/eid3003.231194
PMID:38407166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10902536/
Abstract

This study aimed to estimate the incidence rates of post-COVID-19 fatigue and chronic fatigue and to quantify the additional incident fatigue caused by COVID-19. We analyzed electronic health records data of 4,589 patients with confirmed COVID-19 during February 2020-February 2021 who were followed for a median of 11.4 (interquartile range 7.8-15.5) months and compared them to data from 9,022 propensity score-matched non-COVID-19 controls. Among COVID-19 patients (15% hospitalized for acute COVID-19), the incidence rate of fatigue was 10.2/100 person-years and the rate of chronic fatigue was 1.8/100 person-years. Compared with non-COVID-19 controls, the hazard ratios were 1.68 (95% CI 1.48-1.92) for fatigue and 4.32 (95% CI 2.90-6.43) for chronic fatigue. The observed association between COVID-19 and the significant increase in the incidence of fatigue and chronic fatigue reinforces the need for public health actions to prevent SARS-CoV-2 infections.

摘要

本研究旨在估计 COVID-19 后疲劳和慢性疲劳的发病率，并量化 COVID-19 导致的额外新发疲劳。我们分析了 2020 年 2 月至 2021 年 2 月期间确诊 COVID-19 的 4589 名患者的电子健康记录数据，这些患者中位随访时间为 11.4 个月（四分位距 7.8-15.5），并将其与 9022 名匹配倾向评分的非 COVID-19 对照组的数据进行了比较。在 COVID-19 患者中（15%因急性 COVID-19 住院），疲劳的发病率为 10.2/100 人年，慢性疲劳的发病率为 1.8/100 人年。与非 COVID-19 对照组相比，疲劳的风险比为 1.68（95%CI 1.48-1.92），慢性疲劳的风险比为 4.32（95%CI 2.90-6.43）。COVID-19 与疲劳和慢性疲劳发病率显著增加之间的观察到的关联，强化了采取公共卫生行动预防 SARS-CoV-2 感染的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c9a/10902536/065083513d88/23-1194-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c9a/10902536/8505325734a6/23-1194-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c9a/10902536/77b889dadc18/23-1194-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c9a/10902536/065083513d88/23-1194-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c9a/10902536/8505325734a6/23-1194-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c9a/10902536/77b889dadc18/23-1194-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c9a/10902536/065083513d88/23-1194-F3.jpg

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