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基于不同医学影像和咳嗽声的胸部疾病分类的多模态深度学习方法。

Multi-modal deep learning methods for classification of chest diseases using different medical imaging and cough sounds.

机构信息

Department of Computer Science, School of Systems and Technology, University of Management and Technology, Lahore, Pakistan.

Department of Software Engineering, School of Systems and Technology, University of Management and Technology, Lahore, Pakistan.

出版信息

PLoS One. 2024 Mar 12;19(3):e0296352. doi: 10.1371/journal.pone.0296352. eCollection 2024.

Abstract

Chest disease refers to a wide range of conditions affecting the lungs, such as COVID-19, lung cancer (LC), consolidation lung (COL), and many more. When diagnosing chest disorders medical professionals may be thrown off by the overlapping symptoms (such as fever, cough, sore throat, etc.). Additionally, researchers and medical professionals make use of chest X-rays (CXR), cough sounds, and computed tomography (CT) scans to diagnose chest disorders. The present study aims to classify the nine different conditions of chest disorders, including COVID-19, LC, COL, atelectasis (ATE), tuberculosis (TB), pneumothorax (PNEUTH), edema (EDE), pneumonia (PNEU). Thus, we suggested four novel convolutional neural network (CNN) models that train distinct image-level representations for nine different chest disease classifications by extracting features from images. Furthermore, the proposed CNN employed several new approaches such as a max-pooling layer, batch normalization layers (BANL), dropout, rank-based average pooling (RBAP), and multiple-way data generation (MWDG). The scalogram method is utilized to transform the sounds of coughing into a visual representation. Before beginning to train the model that has been developed, the SMOTE approach is used to calibrate the CXR and CT scans as well as the cough sound images (CSI) of nine different chest disorders. The CXR, CT scan, and CSI used for training and evaluating the proposed model come from 24 publicly available benchmark chest illness datasets. The classification performance of the proposed model is compared with that of seven baseline models, namely Vgg-19, ResNet-101, ResNet-50, DenseNet-121, EfficientNetB0, DenseNet-201, and Inception-V3, in addition to state-of-the-art (SOTA) classifiers. The effectiveness of the proposed model is further demonstrated by the results of the ablation experiments. The proposed model was successful in achieving an accuracy of 99.01%, making it superior to both the baseline models and the SOTA classifiers. As a result, the proposed approach is capable of offering significant support to radiologists and other medical professionals.

摘要

胸部疾病是指影响肺部的多种病症,如 COVID-19、肺癌 (LC)、肺实变 (COL) 等。在诊断胸部疾病时,医生可能会被发烧、咳嗽、喉咙痛等重叠症状所误导。此外,研究人员和医疗专业人员利用胸部 X 光 (CXR)、咳嗽声和计算机断层扫描 (CT) 扫描来诊断胸部疾病。本研究旨在对包括 COVID-19、LC、COL、肺不张 (ATE)、肺结核 (TB)、气胸 (PNEUTH)、水肿 (EDE) 和肺炎 (PNEU) 在内的九种不同的胸部疾病进行分类。为此,我们提出了四种新的卷积神经网络 (CNN) 模型,通过从图像中提取特征,为九种不同的胸部疾病分类训练独特的图像级表示。此外,所提出的 CNN 采用了几种新方法,如最大池化层、批量归一化层 (BANL)、dropout、基于秩的平均池化 (RBAP) 和多方式数据生成 (MWDG)。声谱图方法用于将咳嗽声转换为视觉表示。在开始训练所开发的模型之前,使用 SMOTE 方法对 CXR 和 CT 扫描以及九种不同胸部疾病的咳嗽声图像 (CSI) 进行校准。用于训练和评估所提出模型的 CXR、CT 扫描和 CSI 来自 24 个公开的基准胸部疾病数据集。除了最先进的分类器之外,还将所提出模型的分类性能与七种基线模型(即 Vgg-19、ResNet-101、ResNet-50、DenseNet-121、EfficientNetB0、DenseNet-201 和 Inception-V3)进行了比较。通过消融实验的结果进一步证明了所提出模型的有效性。所提出的模型成功地实现了 99.01%的准确率,优于基线模型和最先进的分类器。因此,所提出的方法能够为放射科医生和其他医疗专业人员提供重要支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d07/10931489/f02595743146/pone.0296352.g001.jpg

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