Department of Gynecology, Taizhou Municipal Hospital, Medical College of Taizhou University, Taizhou, China.
J Cell Mol Med. 2024 Apr;28(8):e18265. doi: 10.1111/jcmm.18265.
Mitochondria and their related genes (MTRGs) are pivotal in the tumour microenvironment (TME) of cervical cancer, influencing prognosis and treatment response. This study developed a prognostic model using MTRGs to predict overall survival (OS) in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), aiming for personalized therapy. Analysing 14 MTRGs like ISCU and NDUFA11 through techniques such as univariate Cox regression, we found that a low mitochondrial (MT) score is associated with better survival, while a high MT score predicts poorer outcomes. The TME score, particularly influenced by CD8 T cells, also correlates with prognosis, with a high score indicating favourable outcomes. The interplay between MT and TME subtypes revealed that the best prognosis is seen in patients with a low MT and high TME score. Our findings highlight the role of MTRGs as potential biomarkers and therapeutic targets in cervical cancer, offering a novel approach to improving patient outcomes through a more nuanced understanding of mitochondrial function and immune interactions within the TME. This model presents a promising avenue for enhancing the precision of prognostic assessments in CESC.
线粒体及其相关基因（MTRGs）在宫颈癌的肿瘤微环境（TME）中起着关键作用，影响预后和治疗反应。本研究利用 MTRGs 构建了一个预测宫颈鳞状细胞癌和宫颈内膜腺癌（CESC）总生存期（OS）的预后模型，旨在实现个体化治疗。通过单变量 Cox 回归等技术分析了 ISCU 和 NDUFA11 等 14 个 MTRGs，我们发现低线粒体（MT）评分与更好的生存相关，而高 MT 评分则预示着更差的结局。TME 评分，特别是受 CD8 T 细胞的影响，也与预后相关，高评分表明预后良好。MT 和 TME 亚型之间的相互作用表明，低 MT 和高 TME 评分的患者预后最佳。我们的研究结果强调了 MTRGs 作为宫颈癌潜在生物标志物和治疗靶点的作用，通过更深入地了解线粒体功能和 TME 中的免疫相互作用，为改善患者预后提供了一种新的方法。该模型为提高 CESC 预后评估的精准性提供了一个有前途的途径。
