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无试剂葡萄糖生物传感器基于铂纳米结构和聚吡咯层的组合。

Reagentless Glucose Biosensor Based on Combination of Platinum Nanostructures and Polypyrrole Layer.

机构信息

Department of Immunology and Bioelectrochemistry, State Research Institute Centre for Innovative Medicine, Santariskiu 5, LT-08406 Vilnius, Lithuania.

NanoTechnas-Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 243, LT-03225 Vilnius, Lithuania.

出版信息

Biosensors (Basel). 2024 Mar 4;14(3):134. doi: 10.3390/bios14030134.

DOI:10.3390/bios14030134
PMID:38534241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10968463/
Abstract

Two types of low-cost reagentless electrochemical glucose biosensors based on graphite rod (GR) electrodes were developed. The electrodes modified with electrochemically synthesized platinum nanostructures (PtNS), 1,10-phenanthroline-5,6-dione (PD), glucose oxidase (GOx) without and with a polypyrrole (Ppy) layer-(i) GR/PtNS/PD/GOx and (ii) GR/PtNS/PD/GOx/Ppy, respectively, were prepared and tested. Glucose biosensors based on GR/PtNS/PD/GOx and GR/PtNS/PD/GOx/Ppy electrodes were characterized by the sensitivity of 10.1 and 5.31 μA/(mM cm), linear range (LR) up to 16.5 and 39.0 mM, limit of detection (LOD) of 0.198 and 0.561 mM, good reproducibility, and storage stability. The developed glucose biosensors based on GR/PtNS/PD/GOx/Ppy electrodes showed exceptional resistance to interfering compounds and proved to be highly efficient for the determination of glucose levels in blood serum.

摘要

开发了两种基于石墨棒 (GR) 电极的低成本无试剂电化学葡萄糖生物传感器。分别制备和测试了用电化学合成的铂纳米结构 (PtNS)、1,10-邻菲啰啉-5,6-二酮 (PD)、葡萄糖氧化酶 (GOx) 修饰的电极，没有和有聚吡咯 (Ppy) 层的电极：(i) GR/PtNS/PD/GOx 和 (ii) GR/PtNS/PD/GOx/Ppy。GR/PtNS/PD/GOx 和 GR/PtNS/PD/GOx/Ppy 电极的葡萄糖生物传感器的特点是灵敏度分别为 10.1 和 5.31 μA/(mM cm)、线性范围 (LR) 分别高达 16.5 和 39.0 mM、检测限 (LOD) 分别为 0.198 和 0.561 mM、具有良好的重现性和储存稳定性。基于 GR/PtNS/PD/GOx/Ppy 电极的开发的葡萄糖生物传感器对干扰化合物具有出色的抵抗力，并被证明在血清中葡萄糖水平的测定中非常有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/c435b139009a/biosensors-14-00134-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/872f48e6f48d/biosensors-14-00134-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/866f03269b31/biosensors-14-00134-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/c7a866443f1b/biosensors-14-00134-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/d0d9a4a70653/biosensors-14-00134-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/87a8a4e8fda8/biosensors-14-00134-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/57ec6ec3d4a3/biosensors-14-00134-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/c435b139009a/biosensors-14-00134-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/872f48e6f48d/biosensors-14-00134-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/866f03269b31/biosensors-14-00134-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/c7a866443f1b/biosensors-14-00134-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/d0d9a4a70653/biosensors-14-00134-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/87a8a4e8fda8/biosensors-14-00134-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/57ec6ec3d4a3/biosensors-14-00134-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b0d/10968463/c435b139009a/biosensors-14-00134-g007.jpg

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