Ryabinina Anna Yu, Bryk Anna A, Blagonravov Mikhail L, Goryachev Vyacheslav A, Mozhaev Andrey A, Ovechkina Vera S
V.A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.
Pathophysiology. 2024 Mar 1;31(1):127-146. doi: 10.3390/pathophysiology31010010.
Changes in lighting accompany modern urbanization trends and can lead to various pathologies based on circadian disturbances. In this study, we assessed the changes in the circadian rhythm of core body temperature (Tcore) and locomotor activity of Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) following exposure to different lighting conditions: extended light phase of the day (16 h-8 h, 20 h-4 h, 24 h-0 h), light pollution, monochromatic light, and bright light therapy. The telemetry data was collected after experimental lighting conditions during periods with standard lighting (12 h of light and 12 h of darkness) and was processed using linear and cosinor analysis. The daily rhythms of rats' parameters persisted in accordance with the standard lighting regime. Tcore changes were observed in both groups compared to the initial period: in WKY, a decrease in Tcore during the darkness and an increase during the light; in SHR, the opposite trend, with Tcore increased during the darkness and decreased during the light phase of the day. A relationship between Tcore and activity was observed with weak correlation. WKY exhibited more pronounced signs of adaptive variation and desynchronization compared to SHR, which could be associated with a wider range of functional capabilities of the organism without cardiovascular pathology.
光照变化伴随着现代城市化趋势，并可能导致基于昼夜节律紊乱的各种病理状况。在本研究中，我们评估了Wistar-Kyoto大鼠（WKY）和自发性高血压大鼠（SHR）在暴露于不同光照条件下（白天延长光照阶段：16小时-8小时、20小时-4小时、24小时-0小时）、光污染、单色光和强光疗法后，核心体温（Tcore）和运动活动的昼夜节律变化。在标准光照（12小时光照和12小时黑暗）期间的实验光照条件后收集遥测数据，并使用线性和余弦分析进行处理。大鼠参数的每日节律按照标准光照模式持续存在。与初始阶段相比，两组均观察到Tcore变化：在WKY中，黑暗期间Tcore降低，光照期间升高；在SHR中，趋势相反，黑暗期间Tcore升高，白天光照阶段降低。观察到Tcore与活动之间存在弱相关性。与SHR相比，WKY表现出更明显的适应性变化和不同步迹象，这可能与无心血管病理的生物体更广泛的功能能力有关。
