杠柳属三萜皂苷及其抗肝纤维化活性。
Triterpenoid saponins from and their anti-liver fibrotic activities.
机构信息
Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
出版信息
J Asian Nat Prod Res. 2024 Jul;26(7):858-864. doi: 10.1080/10286020.2024.2336150. Epub 2024 Apr 4.
A new triterpenoid saponin (), along with five known compounds (), was isolated from Wall. ex DC, of which compounds were obtained for the first time from this plant. The structures were confirmed by the analysis of 1D, 2D NMR, and HR-ESIMS data, and comparison with previous spectral data. Anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of LPS-induced activation of HSC-T6 .
从卫矛科雷公藤属植物中分离得到一个新的三萜皂苷（），以及五个已知化合物（），其中化合物 和 为首次从该植物中分离得到。通过 1D、2D NMR 和 HR-ESIMS 数据分析以及与以往光谱数据的比较，确定了它们的结构。对分离物的抗肝纤维化活性进行了测定，结果表明它们能抑制 LPS 诱导的 HSC-T6 细胞的增殖。
Zotero 插件