全球食源性甲型肝炎疫情：系统评价与荟萃分析。
Global outbreaks of foodborne hepatitis A: Systematic review and meta-analysis.
作者信息
Gandhi Aravind P, Al-Mohaithef Mohammed, Aparnavi P, Bansal Monika, Satapathy Prakasini, Kukreti Neelima, Rustagi Sarvesh, Khatib Mahalaqua Nazli, Gaidhane Shilpa, Zahiruddin Quazi Syed
机构信息
Department of Community Medicine, All India Institute of Medical Sciences, Nagpur, India.
Department of Public Health, College of Health Sciences, Saudi Electronic University, Riyadh, Saudi Arabia.
出版信息
Heliyon. 2024 Mar 29;10(7):e28810. doi: 10.1016/j.heliyon.2024.e28810. eCollection 2024 Apr 15.
Hepatitis A Virus (HAV) is a significant threat in terms of food safety. A systematic literature search with the research question "What are the clinical outcomes of foodborne Hepatitis A virus infections?" was conducted. The pooled estimate of the outcomes-mortality, hospitalization, and severity rates, along with a 95% confidence interval (CI), was estimated. After screening, 33 studies were included for the data extraction and meta-analysis. The pooled prevalence of hospitalization among the HAV-positive patients was estimated to be 32% (95% CI 21-44), with high heterogeneity (I = 98%, p < 0.01). Australia had the highest hospitalization rate, with 82%, followed by Europe (42%). The hospitalization rate showed a significantly increasing trend (beta = 0.015, p=0.002) over the period. The pooled prevalence of mortality among the HAV-positive patients was estimated to be <1%, with low heterogeneity (I = 5%, p = 0.39). A wide range of food products were linked with the HAV outbreaks.
甲型肝炎病毒（HAV）在食品安全方面是一个重大威胁。针对“食源性甲型肝炎病毒感染的临床结果是什么？”这一研究问题进行了系统的文献检索。对结果——死亡率、住院率和严重程度率进行了汇总估计，并给出了95%置信区间（CI）。筛选后，纳入33项研究进行数据提取和荟萃分析。甲型肝炎病毒阳性患者的住院汇总患病率估计为32%（95%CI 21 - 44），异质性较高（I = 98%，p < 0.01）。澳大利亚的住院率最高，为82%，其次是欧洲（42%）。在此期间，住院率呈显著上升趋势（β = 0.015，p = 0.002）。甲型肝炎病毒阳性患者的死亡汇总患病率估计<1%，异质性较低（I = 5%，p = 0.39）。多种食品与甲型肝炎病毒暴发有关。
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