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阿尔茨海默病与肠道微生物组的研究热点和前沿:知识图谱与文本挖掘分析。

Research Hotspots and Frontiers of Alzheimer's Disease and Gut Microbiota: A Knowledge Mapping and Text Mining Analysis.

机构信息

Department of Urology, People's Hospital of Longhua, No.38 Jinglong Jianshe Road, 518109, Shenzhen, China.

The First School of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

出版信息

Mol Neurobiol. 2024 Nov;61(11):9369-9382. doi: 10.1007/s12035-024-04168-7. Epub 2024 Apr 18.


DOI:10.1007/s12035-024-04168-7
PMID:38632152
Abstract

Gut microbiota has been confirmed to be closely related to Alzheimer's disease (AD). Research on gut microbiota and AD has also increased significantly. This study aimed to conduct a bibliometric and visual analysis of published studies related to gut microbiota and AD. Based on the Web of Science Core Collection SCI-Expanded database, we utilize Excel 2019 and visualization analysis tools VOSviewer, Co-Occurrence13.2 (COOC13.2), Citespace, HistCite, and Bibliometrix (R-Tool of R-Studio) for analysis. A total of 1093 related kinds of literature were included, and the number of papers presented an overall increasing trend. The country/region with the most publications is China, the institution is Zhejiang University, the author is Walter J Lukiw from the USA, and the journal is the Journal of Alzheimer's Disease. Hotspot research areas include the relationship between gut microbiota metabolism and AD, AD treatments related to the gut microbiota, and diseases related to AD and gut microbiota. The future research direction may be T cells, NLRP3 inflammasome, and Porphyromonas gingivalis. Studies on AD and gut microbiota have grown rapidly in recent years. Our research results may provide valuable references for readers and help researchers better find new research directions in the future.

摘要

肠道微生物群已被证实与阿尔茨海默病(AD)密切相关。关于肠道微生物群和 AD 的研究也显著增加。本研究旨在对与肠道微生物群和 AD 相关的已发表研究进行文献计量和可视化分析。本研究基于 Web of Science 核心合集 SCI-Expanded 数据库,使用 Excel 2019 和可视化分析工具 VOSviewer、Co-Occurrence13.2(COOC13.2)、Citespace、HistCite 和 Bibliometrix(R-Studio 的 R 工具)进行分析。共纳入了 1093 种相关文献,文献数量呈总体上升趋势。发文量最多的国家/地区是中国,发文机构是浙江大学,发文作者是美国的 Walter J Lukiw,发文期刊是《阿尔茨海默病杂志》。热点研究领域包括肠道微生物群代谢与 AD 的关系、与肠道微生物群相关的 AD 治疗方法以及 AD 和肠道微生物群相关的疾病。未来的研究方向可能是 T 细胞、NLRP3 炎性小体和牙龈卟啉单胞菌。近年来,AD 和肠道微生物群的研究迅速增长。我们的研究结果可能为读者提供有价值的参考,并帮助研究人员在未来更好地找到新的研究方向。

相似文献

[1]
Research Hotspots and Frontiers of Alzheimer's Disease and Gut Microbiota: A Knowledge Mapping and Text Mining Analysis.

Mol Neurobiol. 2024-11

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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本文引用的文献

[1]
Mapping Research Trends and Hotspots in the Link between Alzheimer's Disease and Gut Microbes over the Past Decade: A Bibliometric Analysis.

Nutrients. 2023-7-19

[2]
Knowledge mapping of COVID-19 and autoimmune diseases: a visual and bibliometric analysis.

Clin Exp Med. 2023-11

[3]
Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis.

CNS Neurosci Ther. 2023-10

[4]
Autoimmune diseases and gut microbiota: a bibliometric and visual analysis from 2004 to 2022.

Clin Exp Med. 2023-10

[5]
Research trend of microbiota-gut-brain axis in Alzheimer's disease based on CiteSpace (2012-2021): A bibliometrics analysis of 608 articles.

Front Aging Neurosci. 2022-11-22

[6]
The role of the gut microbiota in multiple sclerosis.

Nat Rev Neurol. 2022-9

[7]
A Bibliometric Review on Gut Microbiome and Alzheimer's Disease Between 2012 and 2021.

Front Aging Neurosci. 2022-7-11

[8]
Tking From Gut to Brain: The Control of Regulatory T Cells Along the Gut-Brain Axis.

Front Immunol. 2022

[9]
The Role of Diet and Interventions on Multiple Sclerosis: A Review.

Nutrients. 2022-3-9

[10]
Challenges and hopes for Alzheimer's disease.

Drug Discov Today. 2022-4

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