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线虫诱捕真菌节丛孢（Arthrobotrys oligospora）通过 G 蛋白偶联受体检测猎物信息素。

The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors.

机构信息

Molecular and Cell Biology, Taiwan International Graduate Program, Academia Sinica and Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan.

Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.

出版信息

Nat Microbiol. 2024 Jul;9(7):1738-1751. doi: 10.1038/s41564-024-01679-w. Epub 2024 Apr 22.

DOI:10.1038/s41564-024-01679-w
PMID:38649409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11724650/
Abstract

The ability to sense prey-derived cues is essential for predatory lifestyles. Under low-nutrient conditions, Arthrobotrys oligospora and other nematode-trapping fungi develop dedicated structures for nematode capture when exposed to nematode-derived cues, including a conserved family of pheromones, the ascarosides. A. oligospora senses ascarosides via conserved MAPK and cAMP-PKA pathways; however, the upstream receptors remain unknown. Here, using genomic, transcriptomic and functional analyses, we identified two families of G protein-coupled receptors (GPCRs) involved in sensing distinct nematode-derived cues. GPCRs homologous to yeast glucose receptors are required for ascaroside sensing, whereas Pth11-like GPCRs contribute to ascaroside-independent nematode sensing. Both GPCR classes activate conserved cAMP-PKA signalling to trigger trap development. This work demonstrates that predatory fungi use multiple GPCRs to sense several distinct nematode-derived cues for prey recognition and to enable a switch to a predatory lifestyle. Identification of these receptors reveals the molecular mechanisms of cross-kingdom communication via conserved pheromones also sensed by plants and animals.

摘要

感知猎物来源线索的能力对于捕食性的生活方式至关重要。在低营养条件下，当暴露于线虫来源的线索（包括一类保守的信息素，即ascarosides）时，寡孢丝孢菌和其他捕食线虫真菌会发展出专门的线虫捕捉结构。寡孢丝孢菌通过保守的 MAPK 和 cAMP-PKA 途径感知ascarosides；然而，上游受体仍然未知。在这里，我们使用基因组、转录组和功能分析，鉴定了两个参与感知不同线虫来源线索的 G 蛋白偶联受体 (GPCR) 家族。与酵母葡萄糖受体同源的 GPCRs 对于 ascaroside 感应是必需的，而 Pth11 样 GPCRs 有助于非 ascarioside 依赖性线虫感应。这两类 GPCR 都激活保守的 cAMP-PKA 信号通路来触发陷阱的发育。这项工作表明，捕食性真菌使用多种 GPCR 来感知几种不同的线虫来源线索，以识别猎物并使其转变为捕食性的生活方式。这些受体的鉴定揭示了通过植物和动物也能感知的保守信息素进行跨域交流的分子机制。

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