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The KMT2A/MLL consensus gene structure: a comprehensive update for research and diagnostic implications.

作者信息

Meyer C, Larghero P, Lopes B A, Marschalek R

机构信息

Goethe-University, Institute of Pharm. Biology/DCAL, Frankfurt/Main, Germany.

GenLAb/Program of Molecular Carcinogenesis, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil.

出版信息

Leukemia. 2024 Jun;38(6):1403-1406. doi: 10.1038/s41375-024-02261-3. Epub 2024 Apr 27.

DOI:10.1038/s41375-024-02261-3
PMID:38678092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11147768/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/115f/11147768/9ee6ca6e860d/41375_2024_2261_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/115f/11147768/9ee6ca6e860d/41375_2024_2261_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/115f/11147768/9ee6ca6e860d/41375_2024_2261_Fig1_HTML.jpg

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2
The role of reciprocal fusions in MLL-r acute leukemia: studying the chromosomal translocation t(4;11).MLL-r 急性白血病中相互易位的作用：研究染色体易位 t(4;11)。
Oncogene. 2021 Oct;40(42):6093-6102. doi: 10.1038/s41388-021-02001-2. Epub 2021 Sep 6.
3
The role of reciprocal fusions in MLL-r acute leukemia: studying the chromosomal translocation t(6;11).
连点成线：染色体外及遗传性DNA扩增的表观遗传调控
J Biol Chem. 2025 Mar 26;301(6):108454. doi: 10.1016/j.jbc.2025.108454.
4
KMT2A-CBL fusion gene in the first reported case of T-cell acute lymphoblastic leukemia associated with Wiedemann-Steiner syndrome.KMT2A-CBL融合基因在首例与维德曼-施泰纳综合征相关的T细胞急性淋巴细胞白血病病例中被报道。
Int J Hematol. 2025 Mar 28. doi: 10.1007/s12185-025-03975-5.
5
Unveiling the Complexity of Rearrangements in Acute Myeloid Leukemias with Optical Genome Mapping.利用光学基因组图谱揭示急性髓系白血病重排的复杂性
Cancers (Basel). 2024 Dec 14;16(24):4171. doi: 10.3390/cancers16244171.
6
Protocol for CRISPR-Cas9-mediated induction of KMT2A rearrangements in cell line and umbilical cord blood hematopoietic stem and progenitor cells.CRISPR-Cas9介导在细胞系和脐带血造血干细胞及祖细胞中诱导KMT2A重排的方案。
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Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription.MLL PHD3 指结合组蛋白 H3K4me3 对于 MLL 依赖性基因转录是必需的。
J Mol Biol. 2010 Jul 9;400(2):137-44. doi: 10.1016/j.jmb.2010.05.005. Epub 2010 May 7.
8
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