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AgNPs-油纳米乳液的绿色制备及抗菌活性评价。

Green Preparation and Antibacterial Activity Evaluation of AgNPs- Oil Nanoemulsion.

机构信息

College of Chinese Medicine Resources, Guangdong Pharmaceutical University, Yunfu 527325, China.

College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Meidicine, Guiyang 550025, China.

出版信息

Molecules. 2024 Apr 26;29(9):2009. doi: 10.3390/molecules29092009.

DOI:10.3390/molecules29092009
PMID:38731501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11085303/
Abstract

Bacterial infection is a thorny problem, and it is of great significance to developing green and efficient biological antibacterial agents that can replace antibiotics. This study aimed to rapidly prepare a new type of green antibacterial nanoemulsion containing silver nanoparticles in one step by using oil (BBO) as an oil phase and tea saponin (TS) as a natural emulsifier and reducing agent. The optimum preparation conditions of the AgNPs@BBO-TS NE were determined, as well as its physicochemical properties and antibacterial activity in vitro being investigated. The results showed that the average particle size of the AgNPs@BBO-TS NE was 249.47 ± 6.23 nm, the PDI was 0.239 ± 0.003, and the zeta potential was -35.82 ± 4.26 mV. The produced AgNPs@BBO-TS NE showed good stability after centrifugation and 30-day storage. Moreover, the AgNPs@BBO-TS NE had an excellent antimicrobial effect on , , and . These results demonstrated that the AgNPs@BBO-TS NE produced in this study can be used as an efficient and green antibacterial agent in the biomedical field.

摘要

细菌感染是一个棘手的问题，开发能够替代抗生素的绿色、高效生物抗菌剂具有重要意义。本研究旨在使用油（BBO）作为油相和茶皂素（TS）作为天然乳化剂和还原剂，一步法快速制备新型含银纳米颗粒的绿色抗菌纳米乳剂（AgNPs@BBO-TS NE）。确定了 AgNPs@BBO-TS NE 的最佳制备条件，并研究了其体外的理化性质和抗菌活性。结果表明，AgNPs@BBO-TS NE 的平均粒径为 249.47±6.23nm，PDI 为 0.239±0.003，zeta 电位为-35.82±4.26mV。离心和 30 天储存后，制备的 AgNPs@BBO-TS NE 表现出良好的稳定性。此外，AgNPs@BBO-TS NE 对 、 、 具有优异的抗菌效果。这些结果表明，本研究制备的 AgNPs@BBO-TS NE 可作为生物医学领域中一种高效、绿色的抗菌剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/2325d1f0fe1f/molecules-29-02009-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/aa0452a9aafd/molecules-29-02009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/7355789490cf/molecules-29-02009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/d2cba9c3b6e0/molecules-29-02009-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/7b2faecf48f2/molecules-29-02009-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/06b4cff59ed8/molecules-29-02009-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/ba2137902857/molecules-29-02009-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/1db9a2703fe1/molecules-29-02009-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/ed06b409ed8c/molecules-29-02009-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/f0de72207935/molecules-29-02009-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/44ac11aac035/molecules-29-02009-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/2325d1f0fe1f/molecules-29-02009-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/aa0452a9aafd/molecules-29-02009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/7355789490cf/molecules-29-02009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/d2cba9c3b6e0/molecules-29-02009-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/7b2faecf48f2/molecules-29-02009-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/06b4cff59ed8/molecules-29-02009-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/ba2137902857/molecules-29-02009-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/1db9a2703fe1/molecules-29-02009-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/ed06b409ed8c/molecules-29-02009-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/f0de72207935/molecules-29-02009-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/44ac11aac035/molecules-29-02009-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35e5/11085303/2325d1f0fe1f/molecules-29-02009-g011.jpg

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